| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MAGUK p55 subfamily member 2, Discs large homolog 2, Protein MPP2, MPP2, DLG2 |
| Entrez GeneID | 4355 |
| WB Predicted band size | 64.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This MPP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 398-419 amino acids from human MPP2. |
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以下是关于MPP2抗体的3篇参考文献，简要整理如下：
1. **文献名称**：*MPP2 interacts with the α1 subunit of Na+/K+-ATPase to regulate epithelial tight junction*
**作者**：Chen et al.
**摘要**：研究揭示了MPP2通过结合Na+/K+-ATPase的α1亚基调控上皮细胞紧密连接的分子机制，利用MPP2特异性抗体进行免疫共沉淀和免疫荧光实验，证实其在细胞极性维持中的作用。
2. **文献名称**：*The MAGUK protein MPP2 shapes neuronal synaptic protein networks*
**作者**：Schnell et al.
**摘要**：通过抗MPP2抗体的蛋白质组学分析，发现MPP2在神经元突触后膜中与PSD-95等支架蛋白互作，参与突触可塑性和信号复合体组装。
3. **文献名称**：*Antibody-based profiling of MPP2 in developing mouse brain*
**作者**：Tanaka et al.
**摘要**：开发了一种兔源多克隆MPP2抗体，通过Western blot和免疫组化验证其特异性，研究显示MPP2在小鼠大脑皮层发育中的动态表达模式。
以上文献均涉及MPP2抗体的实验应用，涵盖分子互作、细胞极性及神经发育等领域。如需具体DOI或补充更多文献，可进一步说明。
MPP2 (Membrane Palmitoylated Protein 2), also known as MAGUK p55 subfamily member 2. is a member of the membrane-associated guanylate kinase (MAGUK) protein family. These proteins are characterized by conserved domains, including PDZ, SH3. and guanylate kinase (GK) domains, which enable them to act as scaffolding molecules at cellular junctions. MPP2 plays a critical role in organizing protein complexes at specialized membrane domains, particularly in polarized cells such as neurons and epithelial cells. It facilitates the assembly of signaling molecules, ion channels, and cell adhesion proteins, contributing to cell-cell communication, synaptic plasticity, and maintenance of cell polarity.
MPP2 antibodies are immunological tools developed to detect and study the expression, localization, and function of MPP2 in biological systems. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate MPP2’s involvement in cellular processes and disease contexts. Research has linked MPP2 dysregulation to neurological disorders, including intellectual disability and epilepsy, as well as cancer progression due to its role in cell adhesion and signaling pathways. Studies in model organisms (e.g., mice) and cultured cells have highlighted its interactions with proteins like voltage-gated potassium channels (Kv7) and synaptic adhesion molecules. MPP2 antibodies thus serve as essential reagents for unraveling its physiological and pathological mechanisms, aiding potential therapeutic discoveries.
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