| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Mitochondrial import inner membrane translocase subunit Tim10 B, Fracture callus protein 1, FxC1, Mitochondrial import inner membrane translocase subunit Tim9 B, TIMM10B, Tim10b, TIMM10B, FXC1, TIM9B, TIMM9B |
| Entrez GeneID | 26515 |
| WB Predicted band size | 11.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This FXC1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 15-48 amino acids from the N-terminal region of human FXC1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于FXC1 (N-term)抗体的模拟参考文献示例(注意：以下内容为虚构，仅供格式参考)：
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1. **文献名称**：*Characterization of FXC1 N-terminal Antibody in Mitochondrial Protein Localization Studies*
**作者**：Smith A, et al.
**摘要**：本研究利用针对FXC1蛋白N端结构域的多克隆抗体，通过免疫荧光和Western blot技术，揭示了FXC1在线粒体外膜中的定位，并验证其与凋亡相关蛋白Bcl-2的相互作用。
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2. **文献名称**：*Development and Validation of a Monoclonal FXC1 (N-term) Antibody for Cancer Biomarker Screening*
**作者**：Lee J, et al.
**摘要**：作者开发了一种高特异性的FXC1 N端单克隆抗体，用于检测多种癌症组织样本中FXC1的表达水平。结果表明，FXC1在乳腺癌中显著上调，可能作为潜在诊断标志物。
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3. **文献名称**：*FXC1 N-terminal Epitope Mapping and Functional Analysis in Neuronal Development*
**作者**：Garcia R, et al.
**摘要**：通过FXC1 (N-term)抗体的表位定位研究，发现其靶向区域对神经突触形成至关重要。敲低实验结合抗体验证显示，FXC1缺失导致神经元分化异常。
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4. **文献名称**：*A Comparative Study of FXC1 Isoforms Using Domain-Specific Antibodies*
**作者**：Wang Y, et al.
**摘要**：本文比较了不同FXC1异构体的表达差异，利用N端抗体和C端抗体进行区分，证实了FXC1-N在应激条件下特异性激活，提示其功能多样性。
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**注意**：以上文献为模拟示例，实际研究中请通过PubMed、Google Scholar等平台，以**“FXC1 antibody”**、**“FXC1 N-terminal epitope”**等关键词检索真实文献。若涉及拼写误差(如FXR1、FOXC1等)，建议核对基因/蛋白名称后再查询。
The FXC1 (N-term) antibody is a polyclonal or monoclonal antibody specifically designed to recognize the N-terminal region of the FXC1 protein, a less-characterized protein implicated in various cellular processes. FXC1 (also known as FAM122A or C7orf50) is evolutionarily conserved and ubiquitously expressed across human tissues, with higher levels observed in the brain, testes, and immune cells. Although its precise molecular function remains under investigation, emerging studies suggest FXC1 may play roles in cell cycle regulation, apoptosis, and transcriptional modulation. It has been reported to interact with protein phosphatase 1 (PP1), potentially influencing phosphatase activity and signaling pathways.
The N-terminal domain of FXC1 is critical for its subcellular localization and protein-protein interactions. Antibodies targeting this region are valuable tools for detecting full-length FXC1 or distinguishing it from truncated isoforms in techniques like Western blotting, immunofluorescence, and immunoprecipitation. Such antibodies aid in elucidating FXC1’s expression patterns, post-translational modifications, and functional mechanisms in both physiological and pathological contexts, including cancer and neurodegenerative diseases. Validation data typically include reactivity in human and rodent samples, with specificity confirmed via knockout/knockdown controls. Commercial sources often provide these antibodies in purified formats, optimized for research applications.
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