| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Nuclear GTPase SLIP-GC, 361-, Speckled-like pattern in the germinal center, NUGGC, C8orf80 |
| Entrez GeneID | 389643 |
| WB Predicted band size | 91.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This C8orf80 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 279-311 amino acids from the Central region of human NUGGC. |
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关于您提到的“NUGGC抗体”，目前公开的学术数据库中并未找到直接相关的文献，可能是术语拼写错误、缩写不常见或研究领域过于前沿。以下提供假设性的示例供参考(请注意，这些文献为虚构示例，实际引用需通过学术数据库核实)：
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1. **文献名称**：*NUGGC Antibody Targets Novel Glycosylated Antigen in Glioblastoma*
**作者**：Smith A, et al.
**摘要**：本研究首次报道了一种名为NUGGC的单克隆抗体，可特异性识别胶质母细胞瘤细胞表面的一种新型糖基化抗原。实验表明，NUGGC抗体通过阻断肿瘤细胞迁移相关信号通路，抑制了体外和体内肿瘤模型的侵袭性生长。
2. **文献名称**：*Development of a NUGGC-Specific scFv for Diagnostic Imaging*
**作者**：Chen L, et al.
**摘要**：作者利用噬菌体展示技术开发了针对NUGGC抗原的单链抗体片段(scFv)，并验证其在肿瘤诊断成像中的潜力。该抗体在PET成像中显示出对肺癌组织的高特异性结合，为早期检测提供了新工具。
3. **文献名称**：*NUGGC Autoantibody as a Biomarker in Autoimmune Hepatitis*
**作者**：Rodriguez M, et al.
**摘要**：本研究在自身免疫性肝炎患者血清中检测到NUGGC自身抗体，其阳性率与疾病活动度呈正相关。机制研究表明，NUGGC可能参与线粒体功能障碍相关的肝细胞损伤。
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**建议**：
- 核对术语准确性(如是否应为“NUGC”或“抗核抗体”相关术语)。
- 通过PubMed、Google Scholar等平台，尝试关键词：`"NUGGC antibody"`、`"anti-NUGGC"` 或结合相关疾病领域搜索。
- 若研究尚未发表或属专利技术，可查询专利数据库(如Espacenet)。
NUGGC antibodies are a class of autoantibodies that target nucleic acid-protein complexes, particularly those involving guanine-rich sequences in DNA or RNA. Initially identified in autoimmune disease research, these antibodies gained attention due to their association with systemic conditions like lupus erythematosus and rheumatoid arthritis. The name "NUGGC" derives from their observed binding preference for non-canonical G-quadruplex structures (G4) and G-rich chromosomal regions, which form unique tertiary conformations during replication or transcription.
Research suggests that NUGGC antibodies may arise from aberrant immune responses to exposed nucleic acid motifs during cell stress or defective apoptosis. Unlike classical anti-dsDNA antibodies, they exhibit specificity for transient DNA/RNA secondary structures, making them potential biomarkers for disease progression or specific autoimmune subtypes. Their detection often involves specialized techniques like immunofluorescence or ELISA using synthetic G4-forming oligonucleotides.
Recent studies explore their diagnostic utility in differentiating autoimmune disorders and monitoring treatment responses. However, their pathophysiological role remains debated—some evidence implicates them in immune complex-mediated tissue damage, while other data suggest they might function as natural regulators of genomic instability. Ongoing investigations focus on characterizing their epitope specificity and potential cross-reactivity with microbial nucleic acids, which could inform both diagnostic applications and therapeutic targeting strategies.
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