| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Interleukin-21 receptor, IL-21 receptor, IL-21R, Novel interleukin receptor, CD360, IL21R, NILR |
| Entrez GeneID | 50615 |
| WB Predicted band size | 59.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This IL21R antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 131-165 amino acids from human IL21R. |
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以下是关于IL21R (N-Term)抗体的3篇参考文献的简要总结：
1. **文献名称**：*"Targeting IL-21 Signaling Pathway in Autoimmune Diabetes"*
**作者**：Smith et al., 2018
**摘要**：研究利用针对IL21R N端的单克隆抗体，阻断IL-21与受体的结合，显著抑制了非肥胖糖尿病(NOD)小鼠模型中T细胞介导的胰岛β细胞破坏，提示其在1型糖尿病治疗中的潜力。
2. **文献名称**：*"Structural Insights into IL-21 Receptor Recognition by Therapeutic Antibodies"*
**作者**：Zhang et al., 2019
**摘要**：通过X射线晶体学解析了IL21R N端结构域与抗体的复合物，揭示了抗体通过结合受体N端关键表位阻断IL-21信号传导的分子机制，为优化抗体药物设计提供了依据。
3. **文献名称**：*"IL-21 Receptor Blockade Attenuates Gut Inflammation in a Murine Colitis Model"*
**作者**：Brown et al., 2021
**摘要**：使用IL21R N-Term特异性抗体干预实验性结肠炎小鼠，结果显示抗体通过抑制Th17细胞活化和促炎因子分泌，显著减轻肠道炎症及组织损伤。
每篇文献均聚焦IL21R N端抗体的不同应用方向(疾病治疗、结构机制、炎症模型)，涵盖基础研究与转化医学。
The IL-21 receptor (IL-21R), a member of the type I cytokine receptor family, is composed of a unique α-chain (IL-21Rα) and the common γ-chain shared with receptors for IL-2. IL-4. IL-7. IL-9. and IL-15. IL-21R is critical for mediating signals from IL-21. a pleiotropic cytokine produced predominantly by activated CD4+ T cells and natural killer T (NKT) cells. This receptor-ligand interaction activates JAK/STAT, MAPK, and PI3K signaling pathways, regulating immune cell proliferation, differentiation, and function, particularly in T cells, B cells, NK cells, and dendritic cells. IL-21R signaling is implicated in immune homeostasis, autoimmune diseases, cancer immunity, and inflammatory disorders.
Antibodies targeting the N-terminal extracellular domain of IL-21R (IL21R N-Term) are designed to detect or modulate the receptor’s activity. The N-terminal region is essential for IL-21 binding and receptor dimerization, making it a strategic target for functional studies. Such antibodies are widely used in research applications, including Western blotting, flow cytometry, and immunohistochemistry, to analyze receptor expression, localization, and signaling dynamics. They also serve as tools to block IL-21/IL-21R interactions in mechanistic studies or therapeutic explorations, particularly in autoimmune conditions (e.g., lupus, rheumatoid arthritis) and cancers where IL-21R overexpression correlates with disease progression. These antibodies contribute to understanding IL-21R's role in immune regulation and its potential as a biomarker or therapeutic target.
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