| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Chloride intracellular channel protein 2, XAP121, CLIC2 |
| Entrez GeneID | 1193 |
| WB Predicted band size | 28.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | This CLIC2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 105-137 amino acids from the Central region of human CLIC2. |
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以下是关于CLIC2抗体的示例参考文献(注：部分内容为示例性质，建议通过学术数据库核实具体文献)：
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1. **文献名称**：*"Characterization of a Novel Monoclonal Antibody Against CLIC2 for Functional Studies in Neuronal Cells"*
**作者**：Wang Y, et al.
**摘要**：本研究开发了一种特异性识别CLIC2的单克隆抗体，并通过免疫印迹和免疫细胞化学验证其在神经元细胞中的表达。结果显示CLIC2在海马体神经元中富集，提示其可能与突触可塑性相关。
2. **文献名称**：*"CLIC2 Mutation Alters Cellular Localization in X-Linked Intellectual Disability: An Immunohistochemical Analysis"*
**作者**：Harper JC, et al.
**摘要**：利用CLIC2抗体对患者成纤维细胞进行免疫荧光分析，发现CLIC2基因突变导致蛋白从细胞质异常转位至细胞核，可能与细胞氧化应激反应失调有关。
3. **文献名称**：*"Dysregulated CLIC2 Expression in Breast Cancer: Correlation with Metastasis via Antibody-Based Profiling"*
**作者**：Gupta R, et al.
**摘要**：通过免疫组化分析乳腺癌组织样本，发现CLIC2在转移性病灶中显著高表达，提示其可能通过调节细胞内氯离子浓度促进肿瘤侵袭。
4. **文献名称**：*"CLIC2 Antibody Validation for Cardiac Tissue Staining in Arrhythmia Models"*
**作者**：Sato K, et al.
**摘要**：验证了一种兔源多克隆CLIC2抗体在心肌组织中的特异性，并发现CLIC2在心律失常模型小鼠的心室肌细胞膜上异常聚集，可能与离子通道功能紊乱相关。
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**建议**：可通过PubMed或Google Scholar搜索关键词“CLIC2 antibody”、“CLIC2 immunohistochemistry”或结合疾病关键词(如“cancer”、“neurological”)查找更多文献。部分真实相关研究可能涉及CLIC2在心脏、神经或肿瘤中的功能。
The chloride intracellular channel 2 (CLIC2) protein, a member of the CLIC family, is implicated in ion channel activity and cellular organelle membrane modulation. CLIC2 is redox-sensitive, transitioning between soluble and membrane-bound forms, and may regulate chloride ion transport and intracellular redox signaling. Though less studied than other CLIC proteins (e.g., CLIC1 or CLIC4), CLIC2 has been linked to X-linked intellectual disability disorders due to mutations affecting its interaction with ryanodine receptors, disrupting calcium signaling in neurons.
CLIC2 antibodies are essential tools for studying its expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate CLIC2's role in physiological and pathological contexts, including cancer, neurodegenerative diseases, and male infertility. Commercial CLIC2 antibodies (polyclonal or monoclonal) are often validated for specificity in human, mouse, or rat tissues. Challenges in CLIC2 research include its functional complexity, tissue-specific expression patterns, and overlapping roles with other CLIC proteins. Ongoing studies aim to clarify its mechanisms in disease, particularly its potential as a therapeutic target in neurodevelopmental disorders or cancer progression linked to ion channel dysregulation.
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