| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | G-protein-signaling modulator 2, Mosaic protein LGN, GPSM2, LGN |
| Entrez GeneID | 29899 |
| WB Predicted band size | 76.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This GPSM2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 113-143 amino acids from human GPSM2. |
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以下是关于GPSM2 (N-Term)抗体的3篇假设性参考文献及其摘要概括，供参考：
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1. **"GPSM2 regulates spindle orientation in epithelial cells via interaction with Gαi"**
*Smith A, et al. (2015).*
本研究利用GPSM2 (N-Term)抗体进行免疫荧光和免疫印迹实验，揭示了GPSM2通过其N端结构域与Gαi蛋白结合，调控上皮细胞分裂时的纺锤体定向，影响组织极性发育。
2. **"Localization of GPSM2 in cochlear hair cells and its role in hearing loss"**
*Zhang Y, et al. (2018).*
作者通过GPSM2 (N-Term)抗体的免疫组化分析，发现GPSM2在耳蜗毛细胞纤毛基体高表达。基因敲除实验表明，GPSM2缺失导致纤毛结构异常，与遗传性耳聋相关。
3. **"Development and validation of a novel GPSM2 N-terminal antibody for protein interaction studies"**
*Johnson R, et al. (2020).*
该文献报道了一种特异性GPSM2 (N-Term)抗体的开发，并通过质谱和敲除细胞系验证其可靠性。抗体成功应用于Co-IP实验，鉴定出GPSM2与LGN蛋白的相互作用网络。
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**注**：以上为模拟示例，实际文献需通过学术数据库(如PubMed、Web of Science)检索确认。若需具体文献，建议结合实验需求补充关键词(如“GPSM2 antibody validation”“N-terminal epitope”)进一步筛选。
The GPSM2 (N-Term) antibody is a specialized tool designed to detect the N-terminal region of G-protein signaling modulator 2 (GPSM2), a protein involved in regulating G-protein-coupled receptor (GPCR) signaling and cell division. GPSM2. also known as LGN or AGS3-like protein, plays critical roles in mitotic spindle orientation, cell polarity, and asymmetric cell division by interacting with Gαi subunits of heterotrimeric G-proteins. This antibody is commonly used in research applications such as Western blotting (WB), immunofluorescence (IF), and immunohistochemistry (IHC) to study GPSM2 expression, localization, and function in cellular processes.
The N-terminal region of GPSM2 contains multiple tetratricopeptide repeat (TPR) domains, which mediate protein-protein interactions essential for its role in guiding spindle positioning during mitosis. Dysregulation of GPSM2 has been linked to developmental disorders, hearing loss, and cancer, making this antibody valuable for investigating disease mechanisms. Validated for specificity in multiple species (e.g., human, mouse, rat), the GPSM2 (N-Term) antibody helps researchers explore tissue-specific expression patterns and its involvement in pathways like planar cell polarity (PCP) and neurodevelopment. Proper controls, such as knockout validation, are recommended to confirm target specificity in experimental settings.
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