| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1, PGC-1-related coactivator, PRC, PPRC1, KIAA0595 |
| Entrez GeneID | 23082 |
| WB Predicted band size | 177.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PPRC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1636-1664 amino acids from the C-terminal region of human PPRC1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PPRC1抗体的参考文献示例(注：以下内容为模拟示例，非真实文献)：
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1. **文献名称**: *PPRC1 regulates mitochondrial biogenesis and metabolic reprogramming in cancer cells*
**作者**: Zhang Y, et al.
**摘要**: 本研究通过Western blot和免疫荧光技术，利用PPRC1抗体揭示了PPRC1在调控癌细胞线粒体生物合成及糖酵解代谢中的关键作用，提示其作为癌症治疗潜在靶点。
2. **文献名称**: *The role of PPRC1 in adipocyte differentiation through interaction with PPARγ*
**作者**: Tanaka K, et al.
**摘要**: 作者使用PPRC1抗体进行免疫共沉淀(Co-IP)实验，证明PPRC1与PPARγ在脂肪细胞分化中的相互作用，并发现其通过调控脂质代谢相关基因表达影响肥胖进程。
3. **文献名称**: *PPRC1 deficiency impairs cardiac energy metabolism and exacerbates heart failure*
**作者**: Smith JL, et al.
**摘要**: 通过免疫组化和小鼠模型，研究发现PPRC1缺失导致心肌细胞能量代谢紊乱，Western blot(使用PPRC1抗体)显示其表达水平与心力衰竭严重程度相关。
4. **文献名称**: *PPRC1-mediated epigenetic regulation in stem cell pluripotency*
**作者**: Chen R, et al.
**摘要**: 该文献通过ChIP-seq(结合PPRC1抗体)和功能实验，揭示PPRC1通过表观遗传修饰维持干细胞多能性，为再生医学提供新机制见解。
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如需真实文献，建议在PubMed或Google Scholar中检索关键词“PPRC1 antibody”或“PPRC1 + [研究领域]”，并筛选应用该抗体的实验研究。
The PPRC1 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Related Coactivator 1) antibody is a tool used to study the PPRC1 protein, a transcriptional coactivator implicated in mitochondrial biogenesis and energy metabolism. PPRC1. also known as PGC-1-related coactivator, shares structural and functional similarities with the PGC-1 family of coactivators, which regulate genes involved in adaptive thermogenesis, oxidative phosphorylation, and cellular energy homeostasis. PPRC1 interacts with nuclear receptors and transcription factors, such as estrogen-related receptor alpha (ERRα), to modulate mitochondrial DNA transcription and metabolic pathways. Its expression is enriched in tissues with high metabolic demand, including brown adipose tissue, heart, and skeletal muscle.
The PPRC1 antibody is commonly employed in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to detect protein expression, localization, and DNA-binding activity. Researchers use it to explore PPRC1's role in metabolic diseases (e.g., obesity, diabetes), neurodegenerative disorders, and cancer, where mitochondrial dysfunction or altered energy metabolism is a hallmark. Commercial PPRC1 antibodies are typically raised in rabbits or mice, validated for specificity via knockdown/knockout controls. Understanding PPRC1's regulatory mechanisms through such antibodies provides insights into metabolic reprogramming and potential therapeutic strategies targeting mitochondrial pathways.
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