| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Complexin-1, Complexin I, CPX I, Synaphin-2, CPLX1 |
| Entrez GeneID | 10815 |
| WB Predicted band size | 15.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This CPLX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-60 amino acids from the Central region of human CPLX1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CPLX1抗体的3篇示例文献摘要(注：文献信息为示例，非真实存在)：
1. **文献名称**：*"Complexin-1 regulates synaptic vesicle exocytosis and interacts with SNARE proteins in mammalian neurons"*
**作者**：Zhang et al.
**摘要**：研究通过CPLX1抗体进行免疫沉淀和免疫荧光实验，揭示了CPLX1通过结合SNARE复合体调控突触囊泡融合的分子机制，并证实其在神经递质释放中的关键作用。
2. **文献名称**：*"Altered CPLX1 expression in schizophrenia: A post-mortem brain analysis"*
**作者**：Thompson et al.
**摘要**：利用CPLX1抗体对精神分裂症患者脑组织进行免疫组化分析，发现前额叶皮层中CPLX1蛋白水平显著降低，提示其可能参与突触功能异常及疾病病理过程。
3. **文献名称**：*"Antibody-based detection of CPLX1 in zebrafish models of neurodevelopmental disorders"*
**作者**：Lee et al.
**摘要**：开发了一种特异性识别斑马鱼CPLX1的多克隆抗体，通过Western blot和共聚焦显微镜验证其可靠性，并用于研究神经发育障碍模型中突触蛋白表达的动态变化。
(如需实际文献，建议通过PubMed或Google Scholar搜索关键词“CPLX1 antibody” + “immunoblot/immunohistochemistry/knockout”获取近期研究。)
The CPLX1 antibody targets complexin-1 (CPLX1), a small synaptic vesicle-associated protein critical for regulating neurotransmitter release. CPLX1. part of the complexin family, acts as a modulator of SNARE complex assembly, balancing synaptic vesicle fusion by inhibiting spontaneous release while promoting evoked exocytosis. It is predominantly expressed in the brain, particularly in presynaptic terminals, and plays a key role in maintaining synaptic plasticity and neuronal communication.
Antibodies against CPLX1 are widely used in neuroscience research to investigate synaptic function, neurodevelopmental disorders, and neurodegenerative diseases like Alzheimer’s. They enable detection and localization of CPLX1 via techniques such as Western blot, immunohistochemistry, and immunofluorescence. Studies utilizing CPLX1 antibodies have revealed its altered expression in conditions such as schizophrenia, epilepsy, and autism, highlighting its potential as a biomarker or therapeutic target.
CPLX1 antibodies are typically validated for specificity using knockout models or siRNA knockdown to confirm minimal cross-reactivity with homologous proteins like CPLX2. Commercial variants include monoclonal and polyclonal options, often derived from rabbit or mouse hosts. Researchers prioritize antibodies with high affinity and low background noise to ensure precise synaptic protein profiling. Overall, CPLX1 antibodies serve as essential tools for unraveling molecular mechanisms underlying synaptic transmission and neurological pathologies.
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