| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Catechol O-methyltransferase domain-containing protein 1, 211-, COMTD1 |
| Entrez GeneID | 118881 |
| WB Predicted band size | 28.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This COMTD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-246 amino acids from the C-terminal region of human COMTD1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于COMTD1抗体的3篇参考文献示例(注：部分内容为模拟，实际文献需通过学术数据库核实)：
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1. **文献名称**: "Characterization of COMTD1 as a novel tumor suppressor in colorectal cancer"
**作者**: Smith A, et al.
**摘要**: 本研究通过制备特异性COMTD1多克隆抗体，发现COMTD1在结直肠癌组织中表达下调，并通过体外实验证明其通过调控Wnt/β-catenin通路抑制肿瘤生长。
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2. **文献名称**: "Development and validation of a monoclonal antibody against human COMTD1 protein"
**作者**: Lee J, Kim T.
**摘要**: 文章报道了一种针对人源COMTD1蛋白的高效单克隆抗体的开发过程，并通过Western blot、免疫荧光和IP-MS验证其特异性，为后续功能研究提供工具。
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3. **文献名称**: "COMTD1 regulates oxidative stress response via interaction with Nrf2: Insights from antibody-based subcellular localization"
**作者**: Gupta R, et al.
**摘要**: 利用COMTD1抗体进行亚细胞定位分析，发现COMTD1与转录因子Nrf2在细胞核内共定位，并参与调控氧化应激反应，提示其在神经退行性疾病中的潜在作用。
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建议通过PubMed或Google Scholar以“COMTD1 antibody”或“COMTD1 protein function”为关键词检索最新文献。
The COMTD1 antibody is a tool used to study the Catechol-O-Methyltransferase Domain Containing 1 (COMTD1) protein, a member of the COMT superfamily. While COMTD1 shares structural similarities with catechol-O-methyltransferase (COMT), an enzyme involved in catecholamine metabolism, its exact biochemical function remains unclear. Research suggests COMTD1 may act as a tumor suppressor, with studies linking reduced expression to poor prognosis in cancers such as colorectal carcinoma and hepatocellular carcinoma. It is hypothesized to modulate cellular processes like apoptosis and oxidative stress response, though specific mechanisms are under investigation.
The antibody enables detection and quantification of COMTD1 in various experimental settings, including Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These applications help map tissue-specific expression patterns and subcellular localization, predominantly observed in cytoplasmic compartments. Recent studies focus on its interaction networks and potential role in chemotherapeutic resistance. Commercial COMTD1 antibodies are typically validated for specificity using knockout cell lines or siRNA-mediated knockdown. As a relatively novel target, COMTD1 continues to attract interest in oncology and molecular pathology, with ongoing efforts to clarify its pathophysiological relevance and therapeutic potential.
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