| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cardiolipin synthase, CLS, 278-, Protein GCD10 homolog, CRLS1, C20orf155, CLS1 |
| Entrez GeneID | 54675 |
| WB Predicted band size | 32.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CRLS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-226 amino acids from the C-terminal region of human CRLS1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CRLS1抗体的3篇参考文献示例(注：文献为虚拟示例，实际引用时需核实真实来源)：
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1. **文献名称**: *CRLS1 modulates mitochondrial cardiolipin composition and promotes cancer cell survival under metabolic stress*
**作者**: Zhang Y, Liu X, Chen L.
**摘要**: 本研究利用CRLS1特异性抗体，通过免疫印迹和免疫荧光技术，揭示了CRLS1在结直肠癌细胞中通过调控心磷脂合成维持线粒体膜稳定性，从而促进肿瘤在缺氧条件下的存活。研究还发现CRLS1高表达与患者预后不良相关。
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2. **文献名称**: *Development of a monoclonal antibody against human CRLS1 and its application in mitochondrial lipidomics*
**作者**: Tanaka K, et al.
**摘要**: 文章报道了一种新型CRLS1单克隆抗体的开发与验证，该抗体通过ELISA和免疫组化显示高特异性。研究者利用此抗体分析不同组织中CRLS1的蛋白表达差异，并发现其与线粒体磷脂代谢紊乱疾病的相关性。
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3. **文献名称**: *CRLS1 deficiency disrupts synaptic plasticity via impaired mitochondrial membrane integrity in Alzheimer's models*
**作者**: Smith J, Patel R, Lee S.
**摘要**: 通过CRLS1抗体检测阿尔茨海默病模型小鼠脑组织，研究发现CRLS1表达下降导致心磷脂合成减少，进而引发线粒体功能障碍和突触可塑性损伤，提示其作为神经退行性疾病的潜在治疗靶点。
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**备注**：以上文献为示例性内容，实际研究中需根据具体需求检索权威数据库(如PubMed、Web of Science)获取真实文献。若需技术类文献，可重点关注抗体开发或应用方向的研究。
The CRLS1 antibody targets cardiolipin synthase 1 (CRLS1), a mitochondrial enzyme critical for synthesizing cardiolipin, a unique phospholipid essential for mitochondrial membrane integrity and bioenergetic functions. CRLS1 catalyzes the final step of cardiolipin biosynthesis by transferring phosphatidyl groups from phosphatidylglycerol to a preexisting cardiolipin scaffold. This lipid is predominantly localized in the inner mitochondrial membrane, where it supports oxidative phosphorylation, mitochondrial dynamics, and apoptosis regulation. Dysregulation of CRLS1 or cardiolipin metabolism is linked to mitochondrial disorders, neurodegenerative diseases (e.g., Barth syndrome), and cancer.
CRLS1 antibodies are vital tools in biomedical research, enabling the detection and quantification of CRLS1 protein expression in tissues or cultured cells via techniques like Western blotting, immunofluorescence, or immunohistochemistry. They help investigate CRLS1's role in mitochondrial dysfunction, metabolic reprogramming in tumors, or responses to cellular stress. Some studies also explore CRLS1 as a potential biomarker or therapeutic target in diseases with impaired mitochondrial lipid homeostasis. Commercial CRLS1 antibodies are typically raised in hosts like rabbits or mice, with validation in specific experimental models. Ongoing research aims to clarify CRLS1's interactions with mitochondrial proteins and its broader implications in cellular health and disease.
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