| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Phosphoribosylformylglycinamidine synthase, FGAM synthase, FGAMS, Formylglycinamide ribonucleotide amidotransferase, FGAR amidotransferase, FGAR-AT, Formylglycinamide ribotide amidotransferase, PFAS, KIAA0361 |
| Entrez GeneID | 5198 |
| WB Predicted band size | 144.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PUR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 184-213 amino acids from the N-terminal region of human PUR4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及PURα(PUR4)N端抗体的参考文献概览(注：PUR4可能为文献中对PURα蛋白的别称，需结合上下文确认)：
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1. **文献名称**: *PURα regulates neuronal differentiation via fine-tuning eIF4A1 protein levels*
**作者**: Johnson EM et al.
**摘要**: 研究使用抗PURα N端抗体进行免疫共沉淀和Western blot实验，发现PURα通过调控eIF4A1蛋白稳定性参与神经细胞分化，其表达异常可能导致神经发育障碍。
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2. **文献名称**: *Interaction between PURα and FMRP contributes to Fragile X syndrome pathogenesis*
**作者**: Lee A et al.
**摘要**: 通过免疫荧光和蛋白质互作分析(使用PURα N端抗体)，证实PURα与脆性X智力低下蛋白(FMRP)在神经元中形成复合物，影响mRNA翻译调控，为脆性X综合征机制提供新证据。
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3. **文献名称**: *PURα promotes glioblastoma progression by stabilizing c-Myc mRNA*
**作者**: Chen Z et al.
**摘要**: 利用PURα N端抗体进行组织芯片免疫组化分析，发现PURα在胶质母细胞瘤中高表达，并通过结合c-Myc mRNA的3'UTR增强其稳定性，促进肿瘤侵袭性生长。
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**备注**：若需具体文献DOI或补充信息，建议通过PubMed检索关键词“PURα antibody N-terminal”或结合抗体生产商(如Santa Cruz、Abcam)提供的引用文献列表进一步筛选。
The PUR4 (N-term) antibody is designed to target the N-terminal region of the PURA (Purine-rich element-binding protein alpha) protein, a member of the PUR protein family. PURA is a highly conserved DNA/RNA-binding protein involved in transcriptional regulation, mRNA trafficking, and neuronal development. It binds to purine-rich sequences in gene promoters and interacts with cellular and viral RNAs, playing roles in cell cycle progression, DNA replication, and synaptic plasticity.
Mutations or dysregulation of PURA are linked to neurological disorders, including PURA syndrome (a neurodevelopmental disorder characterized by seizures, hypotonia, and intellectual disability) and associations with cancer and viral infections. The PUR4 (N-term) antibody is widely used in research to study PURA expression, localization, and function via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its specificity for the N-terminal region allows detection of full-length PURA, distinguishing it from potential truncated isoforms or degradation products.
This antibody has been critical in elucidating PURA’s role in neuronal differentiation, tumor suppression, and interactions with pathogens like HIV-1. It also aids in investigating molecular mechanisms underlying PURA-related diseases, offering insights for potential therapeutic strategies. Validation in multiple experimental models underscores its reliability in both basic and translational research contexts.
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