Rabbit Polyclonal KCNMA1(N-Term) Antibody

The KCNMA1 (N-Term) antibody is a tool for detecting the N-terminal region of the potassium calcium-activated channel subfamily M alpha 1 (KCNMA1) protein, encoded by the KCNMA1 gene. This gene produces the pore-forming α-subunit of large-conductance Ca²⁺-activated K⁺ (BK or Maxi-K) channels, which regulate cellular excitability, muscle contraction, and neurotransmitter release by linking intracellular Ca²⁺ signaling to membrane potential. The N-terminal cytoplasmic domain of BK channels is critical for channel assembly, trafficking, and interaction with regulatory proteins like β-subunits. Antibodies targeting this region (e.g., residues near the N-terminus) are used in applications such as Western blotting, immunofluorescence, and immunohistochemistry to study BK channel expression, localization, and post-translational modifications. Research involving this antibody has elucidated BK channel roles in physiological processes (e.g., vascular tone, neuronal excitability) and diseases, including epilepsy, hypertension, and cancer. Specificity for the N-terminus helps distinguish full-length BK channels from truncated isoforms or degradation products. Validation via knockout controls or peptide blocking is essential due to potential cross-reactivity. Its use has advanced understanding of BK channel dysfunction mechanisms and therapeutic targeting.