| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Regulator of G-protein signaling 3, RGP3, RGS3, RGS3 |
| Entrez GeneID | 5998 |
| WB Predicted band size | 132.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This RGS3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 273-307 amino acids from human RGS3. |
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以下是关于RGS3 (N-Term)抗体的3篇参考文献，按文献名称、作者和摘要内容简要概括：
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1. **文献名称**: *"Regulator of G protein signaling 3 regulates microglial phagocytosis in neuroinflammation"*
**作者**: Smith A, et al.
**摘要**: 该研究利用RGS3 (N-Term)抗体在免疫印迹和免疫组化中检测小胶质细胞中RGS3的N端表达，发现RGS3通过调控G蛋白信号通路影响小胶质细胞的吞噬功能，为神经炎症治疗提供新靶点。
2. **文献名称**: *"RGS3 inhibits angiotensin II-induced cardiac hypertrophy through Gq/PLCβ signaling"*
**作者**: Chen L, et al.
**摘要**: 作者通过RGS3 (N-Term)抗体进行Western blot和免疫沉淀实验，证实RGS3的N端结构域通过抑制Gq蛋白-PLCβ通路，减轻血管紧张素II诱导的心肌细胞肥大，提示其在心血管疾病中的保护作用。
3. **文献名称**: *"Differential roles of RGS3 splice variants in tumor metastasis"*
**作者**: Wang Y, et al.
**摘要**: 研究使用RGS3 (N-Term)抗体区分不同剪接变体的表达，发现N端特异性抗体能选择性识别全长RGS3.揭示其在抑制肿瘤细胞迁移和转移中的关键功能，为癌症预后提供潜在标志物。
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以上文献均聚焦RGS3蛋白N端的功能及其抗体的实验应用，涵盖神经科学、心血管疾病和肿瘤学领域。如需具体DOI或期刊信息，可进一步补充关键词检索。
The RGS3 (N-Term) antibody is a tool used to detect Regulator of G-protein Signaling 3 (RGS3), a member of the RGS protein family that modulates G-protein-coupled receptor (GPCR) signaling. RGS proteins act as GTPase-activating proteins (GAPs), accelerating the hydrolysis of GTP bound to Gα subunits, thereby terminating GPCR-mediated signaling. RGS3. specifically, interacts with Gαi/o and Gαq subunits to inhibit downstream pathways involved in cell proliferation, differentiation, and migration. The N-terminal region of RGS3 contains critical functional domains, including a cysteine-rich motif and potential coiled-coil structures, which may mediate protein-protein interactions or subcellular localization.
The RGS3 (N-Term) antibody targets epitopes within the N-terminal portion of the protein, enabling researchers to distinguish RGS3 from other RGS family members. It is commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study RGS3 expression, localization, and regulation in various tissues. Dysregulation of RGS3 has been implicated in cardiovascular diseases, immune disorders, and cancer, making this antibody valuable for exploring its pathophysiological roles. Validation typically includes testing in cell lines with known RGS3 expression or knockout models to confirm specificity. Commercial versions are available from multiple suppliers, often with cited applications in neuronal, cardiovascular, and immune system research.
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