| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Arrestin-C, Cone arrestin, C-arrestin, cArr, Retinal cone arrestin-3, X-arrestin, ARR3, ARRX, CAR |
| Entrez GeneID | 407 |
| WB Predicted band size | 42.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This ARR3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 77-109 amino acids from the human region of human ARR3. |
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以下是关于 **ARR3 (N-Term)抗体** 的3篇参考文献示例(内容基于公开文献概括，非真实引用)：
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1. **标题**：*"Arrestin-3 (ARR3) N-Terminal Antibody for Localization in Human Retinal Tissue"*
**作者**：Smith A, et al.
**摘要**：通过ARR3 (N-Term)抗体的免疫组化分析，揭示ARR3在人类视网膜视锥细胞中的特异性表达，证明其参与光信号传导调控，并验证抗体在病理样本中的可靠性。
2. **标题**：*"Functional Characterization of ARR3 in Melanoma Using N-Terminal Specific Antibodies"*
**作者**：Lee J, et al.
**摘要**：利用ARR3 (N-Term)抗体进行Western blot和流式细胞术，发现ARR3在黑色素瘤细胞中异常高表达，可能与MAPK信号通路异常激活相关，提示其作为潜在治疗靶点。
3. **标题**：*"Developmental Regulation of ARR3 in Mouse Retina: Insights from N-Terminal Epitope Tagging"*
**作者**：Brown K, et al.
**摘要**：通过ARR3 (N-Term)抗体追踪小鼠视网膜发育过程中ARR3的动态表达，发现其在光受体成熟阶段的关键作用，并证实抗体在小鼠模型中的交叉反应性。
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如需具体文献，建议在PubMed或Google Scholar中搜索关键词：**ARR3 antibody N-Terminal**，并筛选近年的功能研究或抗体验证类论文。
The ARR3 (N-Term) antibody targets the N-terminal region of Arrestin-3 (ARR3), also known as cone arrestin or X-arrestin, a member of the arrestin protein family. Arrestins play a critical role in regulating G protein-coupled receptor (GPCR) signaling by binding to phosphorylated receptors, leading to signal desensitization and receptor internalization. ARR3 is predominantly expressed in retinal cone photoreceptors, where it modulates the phototransduction cascade by quenching light-activated, phosphorylated cone opsins. This ensures timely termination of visual signaling, enabling rapid adaptation to varying light conditions.
The ARR3 (N-Term) antibody is specifically designed to recognize epitopes within the N-terminal domain of ARR3. making it a valuable tool for studying the protein’s expression, localization, and function in retinal tissues. It is widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate ARR3’s role in visual physiology and its association with retinal disorders. Mutations in the ARR3 gene have been linked to X-linked cone dystrophies and other inherited vision impairments, underscoring its clinical relevance. Research utilizing this antibody contributes to understanding disease mechanisms, photoreceptor function, and potential therapeutic strategies for vision-related conditions. Its specificity for the N-terminal region ensures minimal cross-reactivity with other arrestin family members, such as rod-specific Arrestin-1 (SAG).
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