Rabbit Polyclonal MAZ Antibody

MAZ (Myc-associated zinc finger protein), also known as ZNF42. is a transcription factor that regulates the expression of various genes by binding to GC-rich promoter regions. It contains multiple zinc finger domains, enabling interactions with DNA, RNA, and proteins. First identified through its binding to the MYC promoter, MAZ plays dual roles in gene activation and repression, influencing critical processes like cell proliferation, apoptosis, and differentiation. It regulates oncogenes (e.g., MYC, EGFR) and tumor suppressors, linking it to cancer development and progression. MAZ antibodies are essential tools for studying its expression, localization, and function in cellular and disease contexts. These antibodies, often produced in rabbits or mice, are used in techniques like Western blot, ChIP, immunofluorescence, and immunohistochemistry. Researchers employ MAZ antibodies to investigate its aberrant expression in cancers (e.g., colorectal, pancreatic) and neurological disorders, as well as its role in immune regulation and vascular biology. Validation via knockout/knockdown controls ensures specificity, given MAZ's structural similarity to other zinc finger proteins. Its therapeutic potential in targeting oncogenic pathways continues to drive interest in MAZ-related research.