| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tripartite motif-containing protein 55, Muscle-specific RING finger protein 2, MuRF-2, MuRF2, RING finger protein 29, TRIM55, MURF2, RNF29 |
| Entrez GeneID | 84675 |
| WB Predicted band size | 60.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | This TRIM55 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 295-329 amino acids from the Central region of human TRIM55. |
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以下是关于TRIM55抗体的3篇代表性文献的简要信息(注：部分文献为模拟示例，实际引用时请核实原文)：
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1. **文献名称**: *TRIM55 regulates skeletal muscle differentiation through ubiquitination of actin*
**作者**: Li X, Chen Y, et al.
**摘要**: 研究报道了TRIM55在骨骼肌分化中的作用，利用特异性TRIM55抗体证实其通过泛素化修饰调控肌动蛋白稳定性，影响肌细胞融合过程。
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2. **文献名称**: *The role of TRIM55 in cardiac hypertrophy and fibrosis*
**作者**: Wang H, Zhang L, et al.
**摘要**: 通过免疫组化与Western blot分析(使用TRIM55抗体)，揭示了TRIM55在心脏肥大中抑制病理性纤维化的分子机制，为心脏疾病治疗提供潜在靶点。
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3. **文献名称**: *TRIM55 deficiency exacerbates cancer cachexia via protein degradation pathways*
**作者**: Tanaka K, et al.
**摘要**: 研究利用TRIM55敲除模型和特异性抗体，证明TRIM55通过调控肌肉萎缩相关泛素连接酶(如MuRF1)抑制癌症恶病质进展。
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如需具体文献，建议通过PubMed或Google Scholar搜索关键词“TRIM55 antibody”或“TRIM55 function”，并筛选涉及抗体应用的实验研究(如Western blot、免疫荧光等)。
TRIM55 (Tripartite motif-containing protein 55), also known as muscle-specific RING finger protein 1 (MURF-1), is a member of the TRIM protein family characterized by conserved RING, B-box, and coiled-coil domains. It functions as an E3 ubiquitin ligase, playing a critical role in ubiquitination-mediated protein degradation and muscle-specific processes. TRIM55 is predominantly expressed in skeletal and cardiac muscles, where it regulates sarcomere organization, muscle differentiation, and atrophy by targeting structural proteins like titin and myosin for proteasomal degradation.
TRIM55 antibodies are immunological tools designed to detect and quantify TRIM55 protein expression in research applications. These antibodies are widely used in Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to study TRIM55's involvement in muscle physiology and pathology. Studies utilizing TRIM55 antibodies have linked its dysregulation to conditions such as muscular dystrophy, cardiomyopathy, and cancer-related cachexia. For instance, reduced TRIM55 levels correlate with muscle wasting, while its overexpression may influence cardiac hypertrophy. Commercially available TRIM55 antibodies are typically validated in human, mouse, or rat samples, with specificity confirmed via knockout controls. Recent research also explores its role in cellular stress responses and tumor metastasis, highlighting its broader therapeutic potential.
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