| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Gamma-aminobutyric acid type B receptor subunit 1, GABA-B receptor 1, GABA-B-R1, GABA-BR1, GABABR1, Gb1, GABBR1, GPRC3A |
| Entrez GeneID | 2550 |
| WB Predicted band size | 108.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This GABBR1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 18-52 amino acids from human GABBR1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于GABBR1 (N-Term)抗体的参考文献概览(注：文献为示例性内容，实际引用请核实原文)：
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1. **文献名称**：*"Selective Blockade of GABA B Receptor N-Terminal Domain Modulates Synaptic Plasticity"*
**作者**：Smith J et al.
**摘要**：该研究利用针对GABBR1受体N端的特异性抗体，在小鼠海马神经元中发现N端结构域对突触可塑性的调控作用。通过抗体阻断实验证实，GABBR1的N端区域与突触后信号转导相关，可能影响长时程抑制(LTD)过程。
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2. **文献名称**：*"Validation of a Novel Anti-GABBR1 (N-Term) Antibody for Immunohistochemical Applications"*
**作者**：Lee H et al.
**摘要**：本文报道了一种新型GABBR1 N端抗体的开发与验证，通过Western Blot和免疫组化实验证明其特异性。研究对比了野生型与GABBR1敲除小鼠脑组织样本，确认抗体无交叉反应性，并成功应用于人类大脑皮层神经元定位。
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3. **文献名称**：*"Structural Insights into GABA B Receptor Activation Using N-Terminal Domain-Specific Antibodies"*
**作者**：Wang X et al.
**摘要**：通过冷冻电镜技术和N端特异性抗体，本研究解析了GABAB受体在激活状态下的构象变化，揭示N端结构域在配体结合和跨膜信号传递中的关键作用。抗体被用于稳定受体复合物以辅助结构分析。
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如需具体文献DOI或补充更多研究，建议在PubMed或Web of Science中检索关键词：**GABBR1 antibody N-terminal, GABABR1 epitope mapping**。部分开放获取文献(如Nature Communications)可能提供免费全文。
The GABBR1 (N-Term) antibody is designed to target the N-terminal region of the GABA B receptor 1 (GABBR1), a key subunit of the GABAB receptor, which belongs to the class C family of G protein-coupled receptors (GPCRs). GABAB receptors mediate the slow inhibitory effects of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system. The GABBR1 subunit pairs with GABBR2 to form a functional heterodimeric receptor, critical for synaptic transmission, neuronal excitability, and plasticity.
This antibody is commonly used in research applications such as Western blotting, immunohistochemistry, and immunofluorescence to detect GABBR1 expression and localization in tissues or cell models. Targeting the N-terminal domain allows specificity for the full-length receptor, distinguishing it from potential splice variants or degradation products. Studies leveraging this antibody have contributed to understanding GABAB receptor roles in neurological and psychiatric disorders, including epilepsy, anxiety, and addiction, as well as its involvement in modulating neurotransmitter release and synaptic plasticity. Validation of the antibody typically includes testing in GABBR1-knockout models to confirm specificity. Researchers value this tool for exploring receptor trafficking, post-translational modifications, and interactions with downstream signaling partners.
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