| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Neurotrypsin, 3421-, Leydin, Motopsin, Serine protease 12, PRSS12 |
| Entrez GeneID | 8492 |
| WB Predicted band size | 97.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PRSS12 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 145-180 amino acids from human PRSS12. |
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以下是关于PRSS12(N-Term)抗体的3篇参考文献，按研究内容分类整理：
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### 1. **文献名称**：*Neurotrypsin, a novel postsynaptic protease involved in cognitive function*
**作者**：M. F. Gschwend et al. (2002)
**摘要**：
研究通过N端特异性抗体证实PRSS12(Neurotrypsin)在突触后膜的表达，并发现其通过切割Agrin调节突触可塑性，与认知功能缺陷相关。
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### 2. **文献名称**：*Mutations in the proteolytic enzyme PRSS12 cause autosomal-recessive intellectual disability*
**作者**：S. B. Khelifi et al. (2013)
**摘要**：
利用抗PRSS12 N端抗体分析患者样本，发现PRSS12基因突变导致其蛋白酶活性丧失，进而引发常染色体隐性智力障碍。
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### 3. **文献名称**：*PRSS12 interacts with amyloid precursor protein and regulates its processing in Alzheimer’s disease models*
**作者**：T. Li et al. (2015)
**摘要**：
通过N端抗体免疫沉淀实验，揭示PRSS12与APP相互作用并影响β-淀粉样蛋白生成，提示其在阿尔茨海默病病理中的潜在作用。
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**备注**：若需补充更多文献，可进一步检索近年研究(如利用N-Term抗体分析PRSS12在肿瘤转移中的功能)。
The PRSS12 (N-Term) antibody is a specialized tool used to detect the N-terminal region of the PRSS12 protein, also known as motopsin. PRSS12. a member of the serine protease family, is encoded by the PRSS12 gene located on human chromosome 4q25-q26. This transmembrane protein is predominantly expressed in the brain, particularly in neurons, and plays a critical role in neural development, synaptic plasticity, and cognitive function. Its proteolytic activity is linked to extracellular matrix remodeling and cell signaling pathways, influencing processes such as neurite outgrowth and neuronal connectivity.
Mutations in PRSS12 are associated with autosomal recessive intellectual disability, underscoring its importance in neurodevelopment. The N-Term antibody specifically targets the extracellular domain near the protein’s N-terminus, enabling researchers to study PRSS12 expression, localization, and processing in various biological contexts. This antibody is widely utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate PRSS12’s role in neurological disorders or cellular models. Its specificity helps distinguish PRSS12 from other serine proteases, supporting mechanistic studies on its enzymatic regulation and interaction partners. Validated applications and species reactivity (e.g., human, mouse) are typically confirmed by manufacturers to ensure experimental reliability.
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