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Rabbit Polyclonal ATP5EP2 Antibody

  • 中文名: ATP5EP2抗体
  • 别    名: ATP synthase subunit epsilon-like protein, mitochondrial, ATP5EP2
货号: IPDX33414
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesATP synthase subunit epsilon-like protein, mitochondrial, ATP5EP2
WB Predicted band size5.8kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis ATP5EP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 19-52 amino acids from the Central region of human ATP5EP2.

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参考文献

以下是3篇与ATP5EP2抗体相关的文献示例(注:因该基因研究较新,部分文献可能使用其别名ATP5F1E或ATP5ME):

1. **标题**: "ATP5ME regulates cell apoptosis in lung adenocarcinoma via mitochondrial dysfunction"

**作者**: Li Y, et al.

**摘要**: 研究利用ATP5EP2抗体进行Western blot和免疫组化,证明ATP5ME在肺腺癌中高表达,并通过调控线粒体膜电位影响癌细胞凋亡。

2. **标题**: "Interaction between ATP synthase and amyloid-β in Alzheimer's disease models"

**作者**: Smith J, et al.

**摘要**: 通过ATP5EP2抗体的共定位实验,发现ATP5ME与β-淀粉样蛋白在神经元线粒体中的异常互作可能参与阿尔茨海默病病理进程。

3. **标题**: "Proteomic analysis of ATP synthase subunits in human cardiomyocytes"

**作者**: Chen H, et al.

**摘要**: 使用ATP5EP2抗体进行蛋白质组学研究,揭示ATP5ME在心肌细胞能量代谢中的亚基特异性表达及缺血再灌注损伤中的变化规律。

(注:以上文献为模拟示例,实际文献需通过PubMed或Google Scholar以关键词"ATP5EP2 antibody"、"ATP5F1E"等检索获取最新研究。)

背景信息

The ATP5EP2 antibody targets the ATP synthase membrane subunit d (ATP5H), a crucial component of the mitochondrial ATP synthase complex (Complex V). This enzyme catalyzes the final step of oxidative phosphorylation, generating ATP by utilizing the proton gradient across the inner mitochondrial membrane. ATP5EP2 encodes the subunit d of the F0 sector, which forms part of the proton-conducting channel essential for ATP synthesis. Research on ATP5EP2 antibodies primarily focuses on understanding the expression, localization, and function of subunit d in cellular energy metabolism and mitochondrial dynamics. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study ATP synthase assembly, mitochondrial disorders, and diseases linked to energy dysregulation, such as cancer, neurodegenerative conditions, and metabolic syndromes. Additionally, ATP5EP2 antibodies help investigate the role of mitochondrial dysfunction in aging and apoptosis. Validated for specificity in recognizing the target subunit across species, these tools are vital for elucidating molecular mechanisms underlying mitochondrial pathologies and potential therapeutic targets. Proper controls, such as knockout cell lines or peptide competition assays, are recommended to confirm antibody reliability in experimental settings.

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