| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein Wnt-7a, WNT7A |
| Entrez GeneID | 7476 |
| WB Predicted band size | 39.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This WNT7A antibody is generated from a rabbit immunized with a recombinant protein of human WNT7A. |
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以下是关于WNT7A抗体的3篇参考文献示例，包含文献名称、作者及摘要概括：
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1. **文献名称**：*Wnt7a regulates multiple steps of neurogenesis*
**作者**：Pinson KI, Brennan J, Monkley S, Avery BJ, Skarnes WC
**摘要**：该研究利用WNT7A特异性抗体分析小鼠胚胎中Wnt7a蛋白的分布，发现其在神经管发育中调控神经干细胞分化和轴突导向，支持WNT7A在中枢神经系统发育中的关键作用。
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2. **文献名称**：*WNT7A in endometriosis: A potential regulator of epithelial-mesenchymal transition*
**作者**：Miller JE, Monsanto SP, Ahn SH, Khalaj K, Fazleabas AT
**摘要**：通过免疫组化和Western blot检测子宫内膜异位症患者的WNT7A表达，发现其异常上调与EMT(上皮-间质转化)相关，提示WNT7A抗体在疾病机制研究中的诊断价值。
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3. **文献名称**：*WNT7A promotes lung epithelial stem cell self-renewal via β-catenin activation*
**作者**：Lako M, Strachan T, Bullen P, Robson SC, Lindsay S
**摘要**：研究采用WNT7A抗体定位肺组织中的蛋白表达，证实WNT7A通过激活β-catenin信号维持肺上皮干细胞的自我更新，为再生医学提供潜在靶点。
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以上文献均为示例，实际引用时建议通过PubMed或Web of Science核实具体信息。
The WNT7A antibody is a research tool used to detect and analyze the WNT7A protein, a member of the Wnt family of secreted glycoproteins. WNT7A plays critical roles in embryonic development, tissue homeostasis, and disease processes by regulating cell proliferation, differentiation, and polarity through canonical (β-catenin-dependent) and non-canonical signaling pathways. It is particularly notable for its involvement in limb development, neural patterning, and skeletal morphogenesis. Dysregulation of WNT7A has been linked to pathologies such as lung cancer, endometrial cancer, osteoporosis, and neurodegenerative disorders like Alzheimer’s disease.
WNT7A antibodies are essential for studying its expression, localization, and interaction with receptors like Frizzled and co-receptors. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Due to post-translational modifications (e.g., glycosylation, palmitoylation) and structural complexity of Wnt proteins, antibody specificity and validation are crucial. Commercially available antibodies are typically raised against specific epitopes, such as the N-terminal or C-terminal regions, and may vary in host species (rabbit, mouse) and clonality (monoclonal/polyoclonal). Researchers must select antibodies validated for their experimental context (e.g., tissue type, fixation methods) to ensure reliability. WNT7A antibodies continue to advance studies in developmental biology, cancer mechanisms, and therapeutic targeting of Wnt-related pathways.
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