Rabbit Polyclonal RLF Antibody

RLF (Replication Licensing Factor) antibodies are essential tools in studying the molecular mechanisms governing DNA replication and cell cycle regulation. RLFs, including proteins like the minichromosome maintenance (MCM) complex, Cdc6. and Cdt1. ensure that DNA replication occurs once per cell cycle by licensing replication origins during the G1 phase. Dysregulation of RLFs is linked to genomic instability, a hallmark of cancer and other proliferative diseases. Antibodies targeting RLF components enable researchers to investigate their expression, localization, and interactions in normal and pathological conditions. For example, elevated MCM protein levels are observed in malignancies, making them potential biomarkers for cancer diagnosis. RLF antibodies are widely used in techniques like immunofluorescence, Western blotting, and immunohistochemistry to explore replication licensing errors, cell cycle checkpoints, and therapeutic targeting. Recent studies also focus on their role in stem cell biology and neurodegenerative disorders, where replication stress may contribute to disease progression. The development of specific, high-affinity RLF antibodies continues to advance both basic research and clinical applications, offering insights into cell proliferation control and opportunities for targeted therapies.