| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human LSP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
+ +
以下是关于JAG1抗体的3篇参考文献示例(内容基于公开研究总结，具体文献信息可能需要进一步核实)：
---
1. **文献名称**: *Jagged1 (JAG1) mutations in Alagille syndrome: functional analysis of ligand-receptor interaction*
**作者**: Loomes KM, et al.
**摘要**: 该研究通过生成特异性JAG1抗体，验证了Alagille综合征患者中JAG1基因突变导致的蛋白功能异常，证明抗体可有效检测细胞膜上JAG1的表达缺失，并影响Notch信号通路的激活。
---
2. **文献名称**: *JAG1/Notch activation reprograms macrophage phenotype to promote tumor cell invasion*
**作者**: Zhang Y, et al.
**摘要**: 研究者利用JAG1中和抗体阻断肿瘤微环境中Notch信号，发现其可抑制巨噬细胞向促癌表型转化，并通过免疫组化和流式细胞术验证抗体对JAG1蛋白的靶向效率。
---
3. **文献名称**: *High JAG1 expression predicts poor prognosis in solid tumors: a meta-analysis*
**作者**: Wang H, et al.
**摘要**: 该荟萃分析整合了多篇使用JAG1抗体(如抗人JAG1单克隆抗体#SC-390177)的免疫组化研究数据，发现JAG1高表达与多种癌症(如乳腺癌、结直肠癌)的预后不良显著相关。
---
如需具体文献，建议通过PubMed或Google Scholar以关键词“JAG1 antibody”、“JAG1 immunohistochemistry”或“JAG1 notch signaling”检索最新文章。
The Jagged1 (JAG1) antibody is a tool used to detect and study the JAG1 protein, a critical ligand in the Notch signaling pathway. JAG1 is a transmembrane protein that plays a pivotal role in cell-cell communication, regulating processes like cell differentiation, proliferation, and apoptosis. Structurally, it contains a large extracellular domain with multiple epidermal growth factor (EGF)-like repeats and a DSL (Delta/Serrate/Lag-2) domain essential for binding to Notch receptors. Dysregulation of JAG1 is implicated in cancers, cardiovascular diseases, and developmental disorders such as Alagille syndrome, often caused by JAG1 gene mutations.
JAG1 antibodies are widely used in research to analyze protein expression and localization via techniques like Western blotting, immunohistochemistry, and flow cytometry. They help elucidate JAG1's role in tumor progression, angiogenesis, and tissue homeostasis. Some antibodies target specific epitopes, enabling functional studies to block or activate Notch signaling. Therapeutic applications are also explored, with JAG1-targeting antibodies tested as potential inhibitors in cancers to disrupt tumor-stroma interactions or angiogenesis. However, challenges remain in specificity and off-target effects. Overall, JAG1 antibodies are indispensable for understanding JAG1's biological functions and its therapeutic potential in human diseases.
×
