| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Abelson tyrosine-protein kinase 2, Abelson murine leukemia viral oncogene homolog 2, Abelson-related gene protein, Tyrosine-protein kinase ARG, Abl2 {ECO:0000312|EMBL:AAY860391, ECO:0000312|MGI:MGI:87860} |
| WB Predicted band size | 128.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This Mouse Abl2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1011-1044 amino acids from the C-terminal region of Mouse Abl2. |
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以下是3篇关于Mouse Abl2抗体的参考文献(示例为模拟生成，实际文献需根据具体数据库检索)：
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1. **文献名称**：*Abl2/Arg regulates dendritic spine development via phosphorylation of cortactin in hippocampal neurons*
**作者**：Koleske AJ, et al.
**摘要**：该研究探讨Abl2激酶在小鼠海马神经元树突棘形态发生中的作用，通过Western blot和免疫荧光技术验证了特异性抗体的应用，证明Abl2通过磷酸化cortactin调控细胞骨架重组。
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2. **文献名称**：*Abl2 kinase promotes metastatic progression in mouse models of breast cancer*
**作者**：Miller AL, et al.
**摘要**：研究利用基因敲除小鼠和Abl2特异性抗体，揭示Abl2在乳腺癌转移中的功能。免疫组化分析显示Abl2在侵袭性肿瘤细胞中高表达，抗体验证实验确认其与小鼠Abl2蛋白的特异性结合。
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3. **文献名称**：*Genetic ablation of Abl2 alters synaptic plasticity and motor learning in mice*
**作者**：Grove M, et al.
**摘要**：通过构建Abl2敲除小鼠模型，结合免疫沉淀和免疫印迹技术，使用验证过的Abl2抗体证明其在突触可塑性中的必要性。实验表明Abl2缺失导致小鼠运动学习能力受损。
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**提示**：实际文献需通过PubMed或Google Scholar检索关键词(如"Abl2 antibody mouse")获取，建议结合抗体生产商(如CST、Abcam)提供的引用文献列表。
The mouse Abl2 antibody is a tool designed to detect and study the Abelson-related gene (Abl2), also known as Arg, a non-receptor tyrosine kinase belonging to the Abl kinase family. Abl2 shares structural homology with c-Abl (Abl1), including SH3. SH2. and kinase domains, but differs in its N-terminal region, which influences subcellular localization and functional roles. It regulates cytoskeletal dynamics, cell motility, and adhesion by interacting with proteins like cortactin and paxillin. Dysregulation of Abl2 is implicated in cancer progression, particularly in metastasis, and neurological disorders.
The antibody is commonly used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to assess Abl2 expression, localization, and activation in murine models. Its specificity for mouse Abl2 makes it valuable for preclinical studies exploring Abl2's role in tumor invasion, neuronal development, or response to tyrosine kinase inhibitors. Many antibodies target specific phosphorylated residues (e.g., Tyr^272) to study activation states or protein interactions.
Research using this antibody has advanced understanding of Abl2's dual roles in normal physiology and disease, offering insights into therapeutic targeting. Cross-reactivity with human or other species' Abl2 should be validated, as sequence variations may affect antibody performance.
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