| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Retinoic acid receptor gamma, RAR-gamma, Nuclear receptor subfamily 1 group B member 3, RARG, NR1B3 |
| Entrez GeneID | 5916 |
| WB Predicted band size | 50.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This RARG antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 209-243 amino acids from the Central region of human RARG. |
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以下是关于RARG抗体的3篇参考文献示例(文献信息为虚构，仅供示例参考)：
1. **"RARG antibody-based detection of retinoic acid receptor gamma overexpression in chemotherapy-resistant cancers"**
- **作者**: Smith et al., 2018
- **摘要**: 研究利用特异性RARG抗体，通过免疫组化和Western blot分析，揭示了RARG蛋白在化疗耐药性肿瘤组织中的过表达现象，提示其可能作为癌症耐药的潜在生物标志物。
2. **"Functional characterization of RARG antibodies in stem cell differentiation assays"**
- **作者**: Lee & Chen, 2020
- **摘要**: 通过RARG抗体阻断实验，证明RARG在胚胎干细胞向神经谱系分化中的关键作用，抗体特异性验证为研究RARG调控机制提供了工具。
3. **"Development of a high-affinity monoclonal RARG antibody for chromatin immunoprecipitation (ChIP)"**
- **作者**: Garcia et al., 2017
- **摘要**: 报道了一种新型高亲和力RARG单克隆抗体的开发，成功用于ChIP-seq技术，解析了RARG在基因组中的结合位点及其靶基因调控网络。
如需真实文献，建议通过PubMed或Google Scholar以“RARG antibody”、“retinoic acid receptor gamma antibody”等关键词检索。
The retinoic acid receptor gamma (RARG) is a nuclear receptor that regulates gene expression by binding to retinoic acid, a derivative of vitamin A. As a member of the steroid/thyroid hormone receptor superfamily, RARG plays critical roles in cellular differentiation, embryonic development, and homeostasis. RARG antibodies are tools used in research to detect and study the expression, localization, and function of this receptor in various biological contexts.
These antibodies are developed through immunization with RARG-specific antigenic peptides or recombinant proteins, enabling applications like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). Their specificity and sensitivity are validated using knockout controls or siRNA-mediated knockdowns.
RARG has garnered attention in cancer research due to its dysregulation in malignancies such as leukemia, breast cancer, and prostate cancer. Antibodies against RARG help elucidate its role in tumor progression, drug resistance, and interactions with signaling pathways. Additionally, RARG variants have been linked to congenital heart defects, making these antibodies valuable in developmental biology studies.
Recent studies also explore RARG's involvement in reprogramming somatic cells and regulating stem cell pluripotency. As retinoic acid signaling is a therapeutic target, RARG antibodies may aid in drug discovery and biomarker identification. However, cross-reactivity with related receptors (RARA, RARB) remains a challenge, emphasizing the need for rigorous validation in experimental settings.
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