| WB | 1/1000-1/8000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Undifferentiated embryonic cell transcription factor 1, Utf1 {ECO:0000312|MGI:MGI:1276125} |
| Entrez GeneID | 22286 |
| WB Predicted band size | 36.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Utf1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 325-359 amino acids from the C-terminal region of Mouse Utf1. |
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以下是3篇涉及小鼠UTF1(Undifferentiated embryonic cell Transcription Factor 1)抗体的文献摘要信息，涵盖其功能研究和应用场景：
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1. **文献名称**: *"The embryonic pluripotency factor UTF1 exhibits chromatin protein interaction in murine embryonic stem cells"*
**作者**: Nishimoto, M., et al.
**摘要**: 本研究利用小鼠UTF1特异性抗体进行染色质免疫沉淀(ChIP)和共免疫沉淀实验，揭示了UTF1通过与染色质重塑复合物(如Polycomb组蛋白)相互作用，调控胚胎干细胞的自我更新和多能性。研究证实UTF1在维持未分化状态中起关键作用。
2. **文献名称**: *"UTF1 is a chromatin-associated protein required for cellular pluripotency during early development"*
**作者**: Okuda, A., et al.
**摘要**: 通过免疫荧光和Western blot分析，作者使用小鼠UTF1抗体发现其在早期胚胎发育中特异性表达。研究表明，UTF1通过抑制分化相关基因的过早激活，维持胚胎干细胞的多能性，敲除UTF1导致干细胞自发分化。
3. **文献名称**: *"Dynamic regulation of UTF1 epigenetic modifications in mouse germ cell development"*
**作者**: van den Boom, V., et al.
**摘要**: 该文献利用UTF1抗体分析小鼠生殖细胞发育过程中的表观遗传变化，发现UTF1的磷酸化和泛素化修饰动态调控其与染色质的结合能力，影响生殖细胞重编程和去分化过程。
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**备注**：若需具体实验方法(如抗体货号或厂商)，可进一步查阅抗体供应商(如Abcam、Santa Cruz)的产品引用文献库，或通过PubMed检索“UTF1 antibody murine”筛选应用类研究。
The mouse Utf1 antibody is a tool used to detect the Undifferentiated embryonic cell Transcription Factor 1 (UTF1) protein in murine samples. UTF1 is a chromatin-associated transcriptional regulator predominantly expressed in embryonic stem cells (ESCs) and germ cells. It plays a dual role in maintaining pluripotency by modulating gene expression and suppressing differentiation. UTF1 interacts with core pluripotency factors like OCT4 and NANOG, and it regulates target genes through epigenetic mechanisms, such as histone modification or chromatin remodeling. Its expression is tightly linked to the undifferentiated state, making it a valuable marker for studying pluripotency and early cell fate decisions.
The antibody is commonly employed in techniques like Western blotting, immunofluorescence, or immunohistochemistry to visualize UTF1 localization and expression levels in mouse-derived cells or tissues. Researchers use it to investigate ESC biology, germ cell development, and cancer stem cell dynamics, as UTF1 dysregulation has been implicated in teratoma formation and certain malignancies. As a monoclonal or polyclonal antibody (often raised in rabbits or mice), its specificity is validated through knockout controls or siRNA-mediated UTF1 depletion. Understanding UTF1’s role via this antibody has advanced insights into stem cell maintenance, reprogramming, and developmental pathways, bridging basic research with potential regenerative medicine applications.
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