| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Bromodomain-containing protein 7, 75 kDa bromodomain protein, Brd7, Bp75 |
| Entrez GeneID | 26992 |
| WB Predicted band size | 74.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This MOUSE Brd7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 387-418 amino acids from the Central region of human MOUSE Brd7. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于小鼠Brd7抗体的3篇模拟参考文献示例(基于公开领域知识整合，非真实文献)：
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1. **文献名称**：*Brd7 interacts with p53 to regulate chromatin remodeling in murine embryonic stem cells*
**作者**：Dey, A., et al.
**摘要**：本研究利用小鼠Brd7特异性抗体，通过免疫共沉淀和ChIP-seq技术揭示了Brd7与p53蛋白相互作用，共同调控胚胎干细胞中染色质重塑和靶基因转录的机制，证明Brd7在维持基因组稳定性中的作用。
2. **文献名称**：*Development and validation of a monoclonal antibody against mouse Brd7 for cancer studies*
**作者**：Wang, L., et al.
**摘要**：报道了一种针对小鼠Brd7蛋白的高效单克隆抗体的开发，通过Western blot和免疫荧光验证其特异性，并应用于乳腺癌模型中Brd7表达水平与肿瘤抑制功能的相关性研究。
3. **文献名称**：*Brd7 deficiency in mice leads to impaired neuronal differentiation via histone modification*
**作者**：Sasaki, T., et al.
**摘要**：利用Brd7基因敲除小鼠模型及特异性抗体，发现Brd7通过调控组蛋白乙酰化修饰影响神经前体细胞分化，提示其在神经发育疾病中的潜在作用。
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注：以上文献为模拟示例，实际引用请通过PubMed或Google Scholar检索关键词“Brd7 antibody mouse”获取真实文献。
The mouse Brd7 antibody is a monoclonal antibody specifically designed to recognize and bind to the Bromodomain-containing protein 7 (Brd7), a member of the Bromodomain and Extra-Terminal domain (BET) family. Brd7 is a chromatin-associated protein implicated in transcriptional regulation, chromatin remodeling, and cellular processes such as cell cycle progression, differentiation, and apoptosis. It interacts with histone acetyltransferases (e.g., p300) and other chromatin modifiers, playing roles in tumor suppression, particularly in cancers like breast cancer and nasopharyngeal carcinoma.
Mouse-derived Brd7 antibodies are commonly generated using recombinant Brd7 protein fragments or synthetic peptides as immunogens. These antibodies are widely used in research applications such as Western blotting (WB), immunohistochemistry (IHC), immunofluorescence (IF), and immunoprecipitation (IP) to study Brd7 expression, localization, and interactions in human, mouse, or rat samples. Their specificity is validated through knockout/knockdown controls or competitive assays.
As Brd7 dysfunction is linked to cancer and other diseases, these antibodies serve as critical tools for exploring its molecular mechanisms, therapeutic potential, and biomarker utility. Cross-reactivity with Brd7 orthologs in other species depends on epitope conservation. Researchers often prioritize antibodies with high affinity, minimal cross-reactivity, and compatibility with multiple experimental platforms.
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