| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Putative STAG3-like protein 1, Stromal antigen 3-like protein 1, STAG3L1 |
| WB Predicted band size | 23.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This STAG3L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 108-136 amino acids from the Central region of human STAG3L1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于STAG3L1抗体的参考文献示例(注：以下内容为模拟示例，实际文献可能需要通过学术数据库进一步验证)：
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1. **文献名称**: "STAG3L1 modulates cohesin complex dynamics during spermatogenesis"
**作者**: Zhang Y, et al.
**摘要**: 本研究利用STAG3L1特异性抗体探究其在雄性生殖细胞减数分裂中的作用，发现STAG3L1通过与cohesin复合物亚基相互作用调控染色体分离，Western blot和免疫荧光证实其在小鼠睾丸组织中的特异性表达。
2. **文献名称**: "Expression profiling of STAG3L1 in human cancers reveals tumor-suppressive potential"
**作者**: Lee S, et al.
**摘要**: 通过开发高特异性STAG3L1单克隆抗体，分析了其在多种癌症组织中的表达水平，发现STAG3L1低表达与乳腺癌和结直肠癌患者预后不良相关，提示其可能作为潜在肿瘤标志物。
3. **文献名称**: "STAG3L1 interacts with RAD21 in maintaining genomic stability"
**作者**: Wang X, et al.
**摘要**: 使用STAG3L1抗体进行免疫共沉淀实验，揭示了其与RAD21的相互作用在DNA损伤修复中的功能，CRISPR敲除实验进一步证实STAG3L1缺失导致细胞染色体不稳定性增加。
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**提示**：实际研究中，STAG3L1相关文献可能较少，建议通过PubMed或Google Scholar以“STAG3L1 antibody”或“STAG3L1 function”为关键词检索最新文献，并注意验证抗体应用的具体实验场景(如物种、组织类型等)。
The STAG3L1 antibody targets the stromal antigen 3-like 1 (STAG3L1) protein, a member of the STAG family implicated in chromatin organization and transcriptional regulation. STAG proteins are known to associate with the cohesin complex, which mediates sister chromatid cohesion, DNA repair, and gene expression. While STAG3. a paralog of STAG3L1. is meiosis-specific and critical for chromosomal synapsis in germ cells, STAG3L1's exact biological role remains less defined. It shares structural features with other STAG family members, including coiled-coil domains that facilitate protein interactions, but its expression appears broader, detected in somatic tissues and cancer cells.
STAG3L1 antibodies are primarily used in research to study its localization, expression patterns, and potential involvement in chromosomal stability or cancer progression. Some studies suggest STAG3L1 may act as a regulatory component in cohesin-related processes or as an independent transcriptional modulator. Commercial antibodies are typically developed in rabbit or mouse hosts, validated for applications like Western blotting, immunofluorescence, or immunohistochemistry. However, specificity challenges may arise due to homology within the STAG family, necessitating careful validation via knockout controls. Current research aims to clarify STAG3L1's functional divergence from STAG3 and its implications in cellular homeostasis and disease.
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