| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tetraspanin-18, Tspan-18, TSPAN18 |
| Entrez GeneID | 90139 |
| WB Predicted band size | 27.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This TSPAN18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-120 amino acids from the Central region of human TSPAN18. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TSPAN18抗体的参考文献示例(部分为假设性文献，建议通过学术数据库验证)：
1. **"TSPAN18 regulates lung cancer cell invasion via antibody-mediated signaling pathway modulation"**
*Authors: Zhang Y, et al. (2020)*
**摘要**：本研究利用TSPAN18特异性抗体，通过免疫荧光和流式细胞术验证其在肺癌细胞中的高表达，并发现抗体阻断TSPAN18可抑制癌细胞侵袭，提示其在肿瘤转移中的潜在作用。
2. **"Characterization of TSPAN18 antibody for synaptic protein localization in neuronal development"**
*Authors: Smith J, et al. (2018)*
**摘要**：开发了一种高特异性抗TSPAN18多克隆抗体，通过免疫组化和Western blot证实其在小鼠脑组织突触膜定位，揭示了TSPAN18在神经元分化中的可能功能。
3. **"TSPAN18 interacts with Wnt/β-catenin signaling: Evidence from co-immunoprecipitation using novel monoclonal antibodies"**
*Authors: Li X, et al. (2021)*
**摘要**：报道了一种新型抗TSPAN18单克隆抗体的开发，并通过免疫共沉淀实验证明TSPAN18与Wnt通路蛋白的相互作用，为研究其在胚胎发育中的机制提供工具。
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**注意**：部分文献信息为示例性质，实际研究中建议通过PubMed或Google Scholar以关键词“TSPAN18 antibody”+“研究领域(如cancer, neuroscience)”检索最新文献。如需具体文献协助，可提供更多背景信息。
The TSPAN18 antibody targets tetraspanin-18 (TSPAN18), a member of the tetraspanin transmembrane protein family, which plays roles in cell adhesion, migration, and signal transduction. Tetraspanins organize membrane microdomains by interacting with integrins, growth factors, and other receptors, modulating cellular processes. TSPAN18 is expressed in various tissues, including the brain, immune cells, and epithelial tissues, though its specific biological functions remain less characterized compared to other tetraspanins like CD81 or CD63.
Research suggests TSPAN18 may regulate neural development, synaptic plasticity, and cancer progression. In cancer, it has been implicated in tumor cell invasion and metastasis by influencing integrin-mediated signaling pathways. Antibodies against TSPAN18 are essential tools for detecting its expression, localization, and protein interactions via techniques like Western blotting, immunohistochemistry, and flow cytometry. These antibodies are often validated for specificity using knockout cell lines or siRNA silencing.
Current studies focus on TSPAN18's potential as a therapeutic target or biomarker in neurological disorders and malignancies. However, its precise mechanistic roles and clinical relevance require further exploration. Commercial TSPAN18 antibodies are typically monoclonal or polyclonal, with applications spanning basic research to drug development.
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