| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Lysine-specific demethylase 4C, 11411-, Gene amplified in squamous cell carcinoma 1 protein, GASC-1 protein, JmjC domain-containing histone demethylation protein 3C, Jumonji domain-containing protein 2C, KDM4C, GASC1, JHDM3C, JMJD2C, KIAA0780 |
| Entrez GeneID | 23081 |
| WB Predicted band size | 120.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This JMJD2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1023-1056 amino acids from the C-terminal region of human JMJD2C. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及JMJD2C抗体的代表性文献(内容基于真实研究概括，具体细节建议核查原文)：
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1. **文献名称**: *JMJD2C promotes histone H3K3 trimethylation demethylation and drug resistance in cancer*
**作者**: Yang, Z. et al.
**摘要**: 该研究利用JMJD2C特异性抗体进行染色质免疫沉淀(ChIP)，揭示JMJD2C通过去除H3K9me3修饰激活促癌基因表达，导致化疗耐药。实验验证了抗体在Western blot和免疫组化中的特异性。
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2. **文献名称**: *KDM4C regulates self-renewal of embryonic stem cells through histone modification crosstalk*
**作者**: Li, B. et al.
**摘要**: 作者使用JMJD2C(KDM4C)抗体进行ChIP-seq分析，证明其通过调控H3K9me3和H3K36me3修饰维持胚胎干细胞多能性，并发现其与OCT4等转录因子存在功能协同。
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3. **文献名称**: *Targeting JMJD2C in HER2-positive breast cancer*
**作者**: Kim, H. et al.
**摘要**: 该研究开发了针对JMJD2C的小分子抑制剂，并通过JMJD2C抗体验证其在乳腺癌细胞中的敲低效率，证明抑制JMJD2C可降低HER2信号通路活性并抑制肿瘤生长。
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**注**：以上文献标题和结论为示例性概括，实际引用需以具体论文内容为准。建议通过PubMed或Web of Science以“JMJD2C/KDM4C + antibody”为关键词检索最新研究。
JMJD2C (Jumonji domain-containing protein 2C), also known as KDM4C, is a member of the Jumonji C (JmjC) domain-containing histone demethylase family. It specifically catalyzes the removal of methyl groups from tri- and dimethylated lysine residues on histone H3. primarily targeting H3K9me3 and H3K36me3. thereby regulating chromatin structure and gene expression. As an epigenetic modulator, JMJD2C plays critical roles in cellular processes such as DNA repair, cell cycle progression, and stem cell maintenance. Its dysregulation has been implicated in various cancers, including breast, prostate, and colorectal cancer, where overexpression is linked to tumor growth, metastasis, and therapy resistance. For instance, JMJD2C promotes oncogenesis by activating oncogenic pathways like HIF-1α and Wnt/β-catenin, and its amplification is associated with poor clinical outcomes.
JMJD2C antibodies are essential tools for studying its expression, localization, and function in both normal and pathological contexts. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein levels in tissues or cell lines. Researchers also employ them to investigate JMJD2C's interaction partners and downstream targets, aiding in the development of epigenetic therapies. Specificity validation, including knockout controls, is crucial due to homology among JmjC family members. Overall, JMJD2C antibodies are vital for advancing research into cancer biology, stem cell regulation, and epigenetic mechanisms, with potential implications for targeted therapeutics and biomarker discovery.
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