| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/25 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Dihydropyrimidinase-related protein 5, DRP-5, CRMP3-associated molecule, CRAM, Collapsin response mediator protein 5, CRMP-5, UNC33-like phosphoprotein 6, ULIP-6, DPYSL5, CRMP5, ULIP6 |
| Entrez GeneID | 56896 |
| WB Predicted band size | 61.4kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This DPYL5 antibody is generated from a mouse immunized with a recombinant protein of human DPYL5. |
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以下是关于DPYSL5抗体的3篇参考文献(内容基于模拟文献)：
1. **文献名称**：*DPYSL5 regulates neurodevelopmental processes through CRMP signaling in glioblastoma*
**作者**：Lee, S. et al.
**摘要**：研究利用DPYSL5特异性抗体发现其在胶质母细胞瘤细胞中高表达，通过调控CRMP信号通路影响神经元分化和肿瘤侵袭性。
2. **文献名称**：*Monoclonal antibody targeting DPYSL5 reveals its role in axonal guidance and cancer metastasis*
**作者**：Yamaguchi, K. et al.
**摘要**：开发了一种高特异性抗DPYSL5单克隆抗体，证实其在轴突导向中的作用，并发现其表达与肺癌转移相关。
3. **文献名称**：*DPYSL5 as a novel biomarker in colorectal cancer: Validation by immunohistochemical analysis*
**作者**：Chen, H. et al.
**摘要**：通过DPYSL5抗体进行免疫组化分析，证明其在大肠癌组织中的异常表达可作为预后标志物，与患者生存率负相关。
(注：以上文献为示例，实际引用时需检索真实数据库如PubMed获取具体信息。)
The DPYSL5 (Dihydropyrimidinase-like 5) antibody is a tool used to detect and study the DPYSL5 protein, a member of the dihydropyrimidinase-related protein family. DPYSL5. also known as CRMP5. is primarily expressed in the nervous system and plays critical roles in neuronal development, including axon guidance, neurite outgrowth, and synaptic plasticity. It regulates cytoskeletal dynamics by interacting with tubulin and other signaling molecules, influencing cell migration and differentiation. Dysregulation of DPYSL5 has been implicated in neurological disorders, such as Alzheimer’s disease, and cancer, where it may contribute to tumor progression or metastasis.
DPYSL5 antibodies are widely utilized in research to investigate protein expression patterns, subcellular localization, and functional mechanisms in both physiological and pathological contexts. They are essential for techniques like Western blotting, immunohistochemistry, and immunofluorescence. Commercial DPYSL5 antibodies are typically generated using immunogenic peptides or recombinant protein fragments, with validation in specific experimental models. Recent studies highlight its potential as a biomarker in certain cancers, including glioblastoma and lung cancer, driving interest in therapeutic targeting. However, antibody specificity remains a challenge, necessitating careful validation to avoid cross-reactivity with other CRMP family members. Overall, DPYSL5 antibodies are vital for unraveling the protein's multifaceted roles in health and disease.
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