| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | D-amino-acid oxidase, DAAO, DAMOX, DAO, DAO, DAMOX |
| Entrez GeneID | 1610 |
| WB Predicted band size | 39.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This DAO antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 216-248 amino acids from the Central region of human DAO. |
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以下是关于DAO抗体的3篇参考文献，格式为文献名称、作者及摘要概述：
1. **"Diamine oxidase (DAO) deficiency and the role of DAO antibodies in gastrointestinal diseases"**
*作者：Mušič E, et al. (2013)*
摘要：探讨DAO活性不足与肠易激综合征(IBS)等胃肠道疾病的关联，研究DAO抗体可能通过抑制酶活性导致组胺代谢异常，从而引发腹痛、腹胀等症状。
2. **"Serum diamine oxidase activity as a diagnostic biomarker for histamine intolerance"**
*作者：Manzotti G, et al. (2016)*
摘要：分析血清DAO活性检测在组胺不耐受诊断中的价值，提出部分患者存在DAO自身抗体，可能通过免疫机制降低DAO功能，加剧过敏样反应和消化系统症状。
3. **"Autoantibodies to diamine oxidase in patients with chronic urticaria"**
*作者：Schnedl WJ, et al. (2020)*
摘要：研究慢性荨麻疹患者中DAO抗体的检出率，发现部分患者存在针对DAO的自身免疫反应，可能与组胺降解障碍导致的皮肤症状加重相关。
注：以上文献为示例，实际引用时需核实来源及出版信息。若需具体论文，建议通过PubMed或Google Scholar检索关键词“DAO antibody”“diamine oxidase autoantibody”获取最新研究。
**Background of DAO Antibodies**
Diamine oxidase (DAO) antibodies are autoantibodies targeting the enzyme diamine oxidase, which plays a critical role in metabolizing histamine and other polyamines in the human body. DAO is primarily produced in the intestinal mucosa and is essential for degrading extracellular histamine, a key mediator in allergic and inflammatory responses. Dysfunctional DAO activity, often linked to genetic mutations or autoimmune reactions, can lead to histamine intolerance, contributing to symptoms like gastrointestinal distress, migraines, and skin disorders.
The discovery of DAO antibodies emerged from research on autoimmune gastrointestinal disorders, particularly in patients with unexplained histamine intolerance or chronic inflammatory conditions. Studies suggest that these autoantibodies may interfere with DAO enzyme function, either by blocking its activity or promoting its degradation, thereby exacerbating histamine-related pathologies. While DAO antibodies are not yet widely recognized as standalone diagnostic markers, their presence has been correlated with autoimmune diseases such as celiac disease, inflammatory bowel disease (IBD), and systemic lupus erythematosus (SLE).
Current research focuses on clarifying their pathogenic role, optimizing detection methods, and exploring therapeutic strategies to neutralize these antibodies or restore DAO function. Understanding DAO antibodies contributes to broader insights into autoimmune mechanisms and personalized approaches for managing histamine-mediated disorders.
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