Rabbit Polyclonal NACC1 Antibody

The NACC1 (Nucleus Accumbens Associated 1) antibody is a tool used to detect the NACC1 protein, encoded by the *NACC1* gene, which belongs to the NAC (NACC/ BTB) family of transcriptional regulators. NACC1 contains a conserved N-terminal NAC domain and a C-terminal BTB/POZ domain, enabling interactions with chromatin modifiers, ubiquitin ligases, and other proteins. It functions as a transcriptional repressor and a component of ubiquitin ligase complexes, influencing cellular processes like proliferation, differentiation, and apoptosis. Dysregulation of NACC1 is linked to neurodevelopmental disorders (e.g., schizophrenia, autism) and cancers (e.g., glioblastoma, ovarian cancer), where it may act as an oncogene by promoting tumor growth or metastasis. Researchers use NACC1 antibodies in techniques such as Western blot, immunohistochemistry, and immunofluorescence to study its expression, localization, and molecular interactions. These studies aim to clarify its role in disease mechanisms and potential as a therapeutic target. The development of specific NACC1 antibodies has advanced research into its pathological contributions, though challenges remain in understanding its context-dependent functions across tissues and diseases.