| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Neuropeptide Y receptor type 5, NPY5-R, NPY-Y5 receptor, NPYY5-R, Y5 receptor, NPY5R, NPYR5 |
| Entrez GeneID | 4889 |
| WB Predicted band size | 50.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This NPY5R antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 305-341 amino acids from the Central region of human NPY5R. |
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以下是3篇关于NPY5R抗体的参考文献及其摘要概括：
1. **文献名称**：*Development of a monoclonal antibody targeting neuropeptide Y receptor Y5 (NPY5R) for metabolic studies*
**作者**：Smith A, et al.
**摘要**：研究团队开发了一种高特异性NPY5R单克隆抗体，用于检测肥胖模型中受体表达变化。抗体在小鼠脑组织及脂肪细胞中验证，证实其结合活性及在能量代谢调控研究中的潜在应用。
2. **文献名称**：*Characterization of anti-NPY5R antibodies as potential therapeutics for obesity*
**作者**：Chen L, et al.
**摘要**：通过噬菌体展示技术筛选出人源化NPY5R抗体，体外实验显示其可阻断神经肽Y介导的受体激活，并在高脂饮食小鼠模型中显著抑制食欲和体重增长。
3. **文献名称**：*NPY5R-specific antibodies modulate receptor internalization and downstream signaling pathways*
**作者**：Wang Y, et al.
**摘要**：该研究解析了不同NPY5R抗体对受体内吞及cAMP信号通路的调控差异，发现特定表位抗体可选择性抑制β-arrestin招募，为靶向治疗提供新策略。
(注：上述文献为示例性内容，实际引用时需核实真实数据库。)
The neuropeptide Y receptor Y5 (NPY5R) is a G protein-coupled receptor (GPCR) that binds neuropeptide Y (NPY), a key regulator of appetite, energy homeostasis, and stress responses. NPY5R antibodies are essential tools for studying the receptor's expression, localization, and functional roles in physiological and pathological processes. These antibodies are typically generated by immunizing host animals (e.g., rabbits or mice) with peptide sequences derived from specific extracellular or intracellular domains of NPY5R, ensuring specificity through affinity purification and validation via techniques like Western blotting, immunohistochemistry, or flow cytometry.
Research using NPY5R antibodies has revealed its involvement in obesity, metabolic disorders, and neurodegenerative diseases, as NPY5R activation promotes hyperphagia and fat storage. Antibodies enable detection of receptor upregulation in obesity models or altered expression in brain regions linked to anxiety and addiction. Additionally, they aid in evaluating NPY5R-targeted therapies, such as antagonists for weight management. Challenges include distinguishing NPY5R from closely related receptors (e.g., NPY1R/NPY2R) due to sequence homology, requiring rigorous validation using knockout controls. Commercial NPY5R antibodies vary in performance across applications, emphasizing the need for context-specific optimization. Ongoing efforts focus on developing monoclonal antibodies with enhanced specificity to support diagnostic or therapeutic innovations targeting NPY5R pathways.
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