| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MC2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human MC5R |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GPR56抗体的3篇参考文献的简要总结(注：文献信息为模拟示例，实际引用需核实)：
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1. **文献名称**：*GPR56 regulates cortical development and neuronal migration*
**作者**：Piao, X. et al.
**摘要**：该研究通过GPR56特异性抗体发现，GPR56在小鼠大脑皮质发育中通过调控细胞黏附影响神经元迁移，其突变可导致皮质发育畸形。
2. **文献名称**：*GPR56 as a novel biomarker in glioblastoma*
**作者**：Saito, Y. et al.
**摘要**：利用GPR56抗体进行免疫组化分析，发现GPR56在胶质瘤中高表达，并与肿瘤侵袭性和患者预后相关，提示其作为治疗靶点的潜力。
3. **文献名称**：*GPR56 mediates neural crest cell migration*
**作者**：Koirala, S. et al.
**摘要**：研究通过抗体阻断实验证明，GPR56通过结合细胞外基质蛋白调控神经嵴细胞迁移，影响胚胎发育中的组织形成。
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**备注**：实际文献需通过PubMed或Google Scholar检索关键词“GPR56 antibody”获取，并关注近年研究以反映最新进展。
GPR56. a member of the adhesion G protein-coupled receptor (GPCR) family, plays critical roles in diverse biological processes, including cell adhesion, tissue development, and signaling regulation. It is encoded by the *ADGRG1* gene and features a large extracellular N-terminal domain involved in ligand interaction, followed by a seven-transmembrane helical structure typical of GPCRs. GPR56 is highly expressed in the central nervous system, immune cells, and certain cancers, where it modulates pathways like RhoA signaling, influencing cell migration, differentiation, and tumor suppression or progression.
Antibodies targeting GPR56 are essential tools for studying its expression, localization, and function. These antibodies are typically developed against specific epitopes, such as extracellular or intracellular regions, and validated for applications like Western blotting, immunohistochemistry, and flow cytometry. Their specificity is crucial for distinguishing GPR56 from other adhesion GPCRs, given structural similarities within this subfamily. Researchers also utilize GPR56 antibodies to explore its role in diseases; for example, mutations in *ADGRG1* are linked to cortical malformations (e.g., bilateral frontoparietal polymicrogyria), while dysregulated GPR56 expression is associated with cancer metastasis and immune disorders. Recent studies highlight its potential as a therapeutic target, driving demand for high-affinity antibodies to dissect mechanistic pathways or evaluate therapeutic candidates in preclinical models. Robust validation of these antibodies ensures reliability in both basic research and translational contexts.
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