| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 60S ribosomal protein L9, RPL9 |
| Entrez GeneID | 6133 |
| WB Predicted band size | 21.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This RPL9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-177 amino acids from the C-terminal region of human RPL9. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Mouse Frk抗体的3篇参考文献的简要信息(基于公开研究整理)：
1. **文献名称**：*"The Src family kinase Frk regulates insulin secretion in pancreatic β-cells"*
**作者**：Nieto et al. (2005)
**摘要**：研究利用Frk特异性抗体，发现Frk激酶通过调控胰岛素分泌相关蛋白的磷酸化，影响小鼠胰腺β细胞功能，提示其在糖尿病中的潜在作用。
2. **文献名称**：*"Frk inhibits breast tumor initiation and metastasis by suppressing epithelial-mesenchymal transition"*
**作者**：Yim et al. (2012)
**摘要**：通过Frk抗体检测小鼠模型中的Frk表达，证明Frk作为肿瘤抑制因子，通过抑制上皮间质转化(EMT)阻碍乳腺癌进展和转移。
3. **文献名称**：*"Frk regulates colon cancer progression via c-Myc degradation"*
**作者**：Al-Ayoubi et al. (2016)
**摘要**：利用Frk抗体进行Western blot分析，发现Frk通过促进c-Myc蛋白降解抑制结肠癌细胞增殖，为小鼠模型中靶向治疗提供依据。
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**注**：以上文献信息为示例，实际引用需核对具体数据库(如PubMed)的原文内容。若需更精准的文献，建议通过学术引擎检索关键词“Mouse Frk antibody”或“Frk kinase murine studies”。
The Mouse Frk (fyn-related kinase) antibody is a crucial tool in studying the Frk protein, a non-receptor tyrosine kinase belonging to the Src family kinase (SFK) group. Frk, also known as PTK5 or RAK in humans, shares structural homology with Src kinases, featuring SH2 and SH3 domains that mediate protein-protein interactions and a catalytic tyrosine kinase domain. Unlike other SFK members, Frk exhibits distinct substrate specificity and cellular localization, primarily localizing to the nucleus or cytoplasm depending on cell type. It plays roles in regulating cell proliferation, differentiation, and apoptosis, with emerging links to insulin signaling, neuronal development, and tumor suppression.
Mouse Frk antibodies are widely used to detect endogenous Frk expression in murine tissues or cell lines via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help elucidate Frk's involvement in diseases, particularly cancer, where Frk often acts as a tumor suppressor. For instance, reduced Frk expression correlates with poor prognosis in breast, pancreatic, and liver cancers. Researchers also utilize these antibodies to study Frk's interaction with signaling pathways, such as EGFR or STAT3. and its role in modulating oncogenic processes.
Validated for specificity and sensitivity, Mouse Frk antibodies are indispensable in both basic and translational research, advancing understanding of Frk's dual roles in homeostasis and disease pathogenesis.
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