| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cytochrome P450 2W1, 11414-, CYPIIW1, CYP2W1 |
| Entrez GeneID | 54905 |
| WB Predicted band size | 53.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CYP2W1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-33 amino acids from the N-terminal region of human CYP2W1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于CYP2W1 (N-term)抗体的3篇参考文献的简要概括：
1. **文献名称**：*CYP2W1 is highly expressed in adrenal glands and regulated by ACTH*
**作者**：Karlsson et al. (2010)
**摘要**：研究利用针对CYP2W1 N端的抗体，通过免疫组化检测其在肾上腺组织中的高表达，并发现其表达受促肾上腺皮质激素(ACTH)调控，可能参与类固醇代谢。
2. **文献名称**：*CYP2W1 as a potential target for antibody-based therapy in colorectal cancer*
**作者**：Gomez et al. (2012)
**摘要**：该文献使用CYP2W1 N端特异性抗体进行Western blot和免疫荧光实验，发现其在结直肠癌组织中高表达，并探索其作为抗体药物偶联物(ADC)靶点的潜力。
3. **文献名称**：*Expression and prognostic significance of CYP2W1 in neuroblastoma*
**作者**：Strömberg et al. (2015)
**摘要**：通过CYP2W1 N端抗体的免疫组化分析，揭示CYP2W1在神经母细胞瘤中的表达与患者预后不良相关，提示其可能作为肿瘤标志物。
以上研究均利用CYP2W1 N端抗体验证蛋白表达及功能，聚焦其在肿瘤或代谢中的潜在应用。如需具体DOI或期刊信息可进一步补充。
The CYP2W1 (N-term) antibody targets the N-terminal region of cytochrome P450 family 2 subfamily W member 1 (CYP2W1), a protein encoded by the CYP2W1 gene. This enzyme belongs to the cytochrome P450 superfamily, which plays critical roles in drug metabolism, steroid synthesis, and detoxification. Unlike many CYPs expressed in the liver, CYP2W1 exhibits restricted expression in healthy adult tissues but is notably upregulated in certain cancers, including colorectal carcinoma, neuroblastoma, and hepatocellular carcinoma. Its N-terminal region contains a hydrophobic signal-anchor sequence that directs its localization to the endoplasmic reticulum or Golgi apparatus.
Research suggests CYP2W1 may metabolize endogenous substrates or activate prodrugs in tumor tissues, making it a potential therapeutic target or diagnostic biomarker. The CYP2W1 (N-term) antibody is widely used in immunohistochemistry (IHC), western blotting, and immunofluorescence to study its expression patterns, subcellular localization, and association with tumor progression. Studies have linked elevated CYP2W1 levels to poor clinical outcomes, though its exact physiological and pathological mechanisms remain under investigation. This antibody specifically recognizes epitopes near the N-terminus, helping researchers distinguish full-length CYP2W1 from potential cleavage products or isoforms. Its development supports ongoing exploration of CYP2W1's role in cancer biology and targeted therapy strategies.
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