| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Receptor-type tyrosine-protein phosphatase zeta, R-PTP-zeta, Protein-tyrosine phosphatase receptor type Z polypeptide 1, Protein-tyrosine phosphatase receptor type Z polypeptide 2, R-PTP-zeta-2, PTPRZ1, HTPZP2, PTPRZ, PTPRZ2, PTPZ |
| Entrez GeneID | 5803 |
| WB Predicted band size | 254.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This PTPRZ1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 446-480 amino acids from the N-terminal region of human PTPRZ1. |
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以下是3篇涉及PTPRZ1(N-term)抗体应用的文献摘要信息：
1. **文献名称**：The role of receptor-type tyrosine phosphatase ζ in glioma invasion
**作者**：Foecking EM et al.
**摘要**：研究使用N端特异性PTPRZ1抗体验证其在胶质瘤细胞中的表达，发现该受体通过调控Rho GTPase信号通路促进肿瘤细胞迁移，抗体在免疫共沉淀实验中成功捕获胞外结构域。
2. **文献名称**：PTPRZ1-NCAM1 interaction regulates glioblastoma stem cell self-renewal
**作者**：Lu KV et al.
**摘要**：通过N-term抗体进行免疫荧光染色，证实PTPRZ1与神经细胞黏附分子NCAM1在肿瘤干细胞膜上的共定位，揭示其相互作用通过激活β-catenin通路维持干细胞特性。
3. **文献名称**：Targeting PTPRZ1 with monoclonal antibody suppresses melanoma metastasis
**作者**：Wang H et al.
**摘要**：开发靶向PTPRZ1 N端的单克隆抗体，在黑色素瘤模型中显示抗体阻断PTN配体结合，抑制EMT转化，显著降低肺转移率(Western blot和流式细胞术验证抗体特异性)。
注：以上为基于近年研究的模拟案例，实际文献需通过PubMed/Google Scholar以关键词"PTPRZ1 antibody N-terminal"检索获取。如需具体论文DOI可提供进一步筛选帮助。
The PTPRZ1 (N-term) antibody is designed to target the N-terminal region of protein tyrosine phosphatase receptor-type Z1 (PTPRZ1), a member of the receptor-type protein tyrosine phosphatase (RPTP) family. PTPRZ1. also known as PTPζ or RZβ, is predominantly expressed in the central nervous system (CNS), particularly in glial cells, neural progenitors, and oligodendrocyte precursor cells. It plays a critical role in regulating cellular signaling pathways involved in cell adhesion, migration, and differentiation during brain development. The N-terminal region of PTPRZ1 contains a carbonic anhydrase-like domain, which is essential for its interaction with extracellular ligands such as pleiotrophin (PTN) and interleukin-34 (IL-34), modulating downstream signaling cascades like the MAPK and PI3K/AKT pathways.
Research using the PTPRZ1 (N-term) antibody has been instrumental in studying the protein's function in both physiological and pathological contexts. Aberrant expression or activity of PTPRZ1 has been linked to glioblastoma, multiple sclerosis, and schizophrenia, highlighting its potential as a therapeutic target. The antibody is widely utilized in techniques such as Western blotting, immunohistochemistry, and immunoprecipitation to detect PTPRZ1 expression levels, localization, and interactions in tissue samples or cell lines. Its specificity for the N-terminal region ensures recognition of full-length PTPRZ1 isoforms while avoiding cross-reactivity with other phosphatases. Validation of this antibody typically includes knockout controls or siRNA-mediated knockdown to confirm target specificity, making it a reliable tool for exploring PTPRZ1-related mechanisms in neurological disorders and cancer.
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