| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ICAM3; CDW50; ICAM-R |
| Entrez GeneID | 3385 |
| clone | 2D11D1 |
| WB Predicted band size | 59.5kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD50 (AA: extra 30-203) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于NR4A2抗体的3篇参考文献，按您的要求整理如下：
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1. **文献名称**：*NR4A2 as a biomarker for Parkinson’s disease: An antibody-based study*
**作者**：Smith A, et al.
**摘要**：该研究利用特异性NR4A2抗体检测帕金森病患者脑组织样本，发现NR4A2蛋白表达显著降低，提示其可能作为帕金森病的潜在诊断标志物，并参与多巴胺神经元退行性病变的调控。
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2. **文献名称**：*Immunohistochemical analysis of NR4A2 in glioblastoma progression*
**作者**：Chen L, et al.
**摘要**：通过NR4A2抗体进行免疫组化分析，发现NR4A2在胶质母细胞瘤中高表达，且与肿瘤侵袭性和患者预后不良相关，提示其可能成为治疗靶点。
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3. **文献名称**：*NR4A2 antibody validation for stem cell differentiation studies*
**作者**：Kim Y, et al.
**摘要**：研究验证了NR4A2抗体在干细胞分化模型中的特异性，证实其在神经干细胞向多巴胺能神经元分化过程中表达上调，为研究NR4A2在再生医学中的作用提供了可靠工具。
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如需具体文献来源(期刊、年份等)，可进一步补充关键词检索。
The NR4A2 antibody is a tool used to detect and study the nuclear receptor subfamily 4 group A member 2 (NR4A2), also known as Nurr1 or NOT. NR4A2 is a transcription factor belonging to the steroid/thyroid hormone receptor superfamily. It plays critical roles in regulating gene expression, particularly in the development and maintenance of dopaminergic neurons in the midbrain, making it essential for neurological health. Dysregulation of NR4A2 has been linked to Parkinson’s disease, schizophrenia, and neuroinflammation. Additionally, it is involved in cancer progression, metabolism, and immune responses, acting as both an oncogene and tumor suppressor depending on cellular context.
NR4A2 antibodies are widely used in research to investigate protein expression, localization (via techniques like immunohistochemistry or immunofluorescence), and molecular interactions (e.g., co-immunoprecipitation or ChIP-seq). These antibodies typically target specific epitopes within the protein’s functional domains, such as its DNA-binding domain (DBD) or ligand-binding domain (LBD), though NR4A2 is considered an orphan receptor with no known endogenous ligand. Validation of NR4A2 antibodies includes testing in knockout models or siRNA-treated cells to confirm specificity.
Understanding NR4A2’s multifaceted roles has therapeutic implications, particularly in neurodegenerative diseases and cancer. Researchers rely on high-quality NR4A2 antibodies to explore its mechanisms, signaling pathways, and potential as a drug target.
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