| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Oligodendrocyte transcription factor 3, Oligo3, Class B basic helix-loop-helix protein 7, bHLHb7, Oligodendrocyte-specific bHLH transcription factor 3, Olig3, Bhlhb7 |
| Entrez GeneID | 94222 |
| WB Predicted band size | 29.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This Mouse Olig3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 70-103 amino acids from the Central region of Mouse Olig3. |
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以下是关于Mouse Olig3抗体的3篇参考文献及其摘要概括：
1. **"Olig3 regulates the territorial delineation of thalamic nuclei"**
- 作者：Takebayashi H, et al.
- 摘要：研究利用Olig3抗体揭示该转录因子在小鼠胚胎后脑区域神经前体细胞中的表达，发现Olig3对丘脑核团边界的形成及特定神经元亚型的分化起关键作用。
2. **"Olig2 and Olig3 function in the development of cerebellar neurons and glia"**
- 作者：Furusho M, et al.
- 摘要：通过Olig3抗体标记，发现Olig3与Olig2在小鼠小脑发育中协同调控颗粒神经元前体细胞的迁移与分化，并影响部分胶质细胞谱系的命运决定。
3. **"Olig3 controls the differentiation of neural stem cells into sensory interneuron subtypes"**
- 作者：Zhou Q, et al.
- 摘要：研究使用Olig3抗体检测小鼠脊髓发育过程，表明Olig3通过抑制特定转录通路，引导神经干细胞向脊髓感觉中间神经元亚型分化。
4. **"Dynamic expression of Olig3 in the developing mouse spinal cord"**
- 作者：Liu Y, et al.
- 摘要：利用Olig3抗体进行时空表达分析，发现其在脊髓背侧神经前体细胞中短暂表达，调控中间神经元的多样性生成及轴突路径导向。
建议通过PubMed或Google Scholar以“Olig3 antibody mouse”为关键词检索最新文献，以获取更具体的实验应用及抗体验证信息。
The mouse Olig3 antibody is a crucial tool for studying the role of Olig3. a transcription factor belonging to the Olig family (Olig1. Olig2. Olig3), which plays essential roles in neural development. Olig3 is specifically expressed in progenitor cells of the dorsal neural tube during embryogenesis, contributing to the specification of distinct neuronal subtypes in the brainstem, spinal cord, and dorsal spinal cord regions. It is particularly associated with the development of relay neurons in the thalamus and inhibitory interneurons in the dorsal spinal cord.
This antibody is typically produced in rabbits or mice using immunogenic peptides or recombinant proteins corresponding to conserved regions of the mouse Olig3 protein. It is widely used in techniques like immunohistochemistry (IHC), immunofluorescence (IF), and Western blotting (WB) to detect Olig3 expression in tissue sections or cell lysates. Validated for specificity, it helps researchers explore Olig3's regulatory mechanisms in neural patterning, cell fate determination, and its potential involvement in neurological disorders or brain tumorigenesis.
Studies utilizing the mouse Olig3 antibody have advanced understanding of developmental biology, particularly in mapping neural progenitor domains and investigating congenital defects linked to dorsal neural tube malformations. Its application is critical in models studying neurodevelopmental diseases or spinal cord injury repair.
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