| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/25 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GTPase ERas, E-Ras, Embryonic stem cell-expressed Ras, Eras |
| Entrez GeneID | 353283 |
| WB Predicted band size | 24.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Eras antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 19-52 amino acids from the N-terminal region of mouse Eras. |
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以下是关于小鼠Eras(N-term)抗体的3篇模拟参考文献示例(注：文献为虚构，仅供格式参考)：
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1. **标题**: *Characterization of ERAS Protein Expression in Mouse Embryonic Stem Cells Using a Novel N-terminal Specific Antibody*
**作者**: Tanaka A, et al.
**期刊**: *Stem Cell Reports*, 2018.
**摘要**: 本研究开发并验证了一种针对小鼠Eras蛋白N端结构域的高特异性多克隆抗体。通过Western blot和免疫荧光分析，证明该抗体可特异性识别小鼠胚胎干细胞中的Eras蛋白，并发现Eras在维持干细胞未分化状态中起关键作用。
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2. **标题**: *ERAS-Nterm Antibody Reveals Oncogenic Role of ERAS in Spontaneous Tumorigenesis*
**作者**: Smith JL, et al.
**期刊**: *Oncogene*, 2020.
**摘要**: 利用针对Eras-N端的单克隆抗体，研究者发现Eras在转基因小鼠模型中异常激活Ras/MAPK信号通路，促进肿瘤发生。抗体通过免疫组化证实了Eras在肿瘤组织中的高表达，为靶向治疗提供潜在标志物。
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3. **标题**: *Validation of ERAS Knockout Mice Using N-terminal Epitope-Specific Antibodies*
**作者**: Chen H, et al.
**期刊**: *PLOS ONE*, 2019.
**摘要**: 研究通过CRISPR技术构建Eras基因敲除小鼠，并使用N端特异性抗体验证了Eras蛋白的缺失。该抗体在野生型小鼠组织中检测到约27 kDa的条带，而在敲除模型中完全消失，确认了抗体的高特异性及基因敲除有效性。
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**注意**：以上文献为模拟内容，实际研究中请通过PubMed、Google Scholar等平台检索真实文献(关键词：*Mouse ERAS antibody N-terminal*)。若需具体文献协助，建议补充抗体货号或相关研究背景。
The Mouse Eras (N-term) antibody is designed to detect the N-terminal region of the Embryonic Stem Cell-Expressed Ras (Eras) protein, a member of the Ras GTPase superfamily. Eras is predominantly expressed in embryonic stem cells (ESCs) and plays a critical role in maintaining pluripotency and self-renewal by modulating signaling pathways such as PI3K/Akt and MAPK. Unlike classical Ras proteins, Eras lacks intrinsic GTPase activity, leading to constitutive activation and sustained downstream signaling. Its expression is tightly regulated during early embryogenesis but declines upon differentiation, suggesting its importance in early developmental stages.
Research using the Mouse Eras (N-term) antibody has been pivotal in studying Eras's function in stem cell biology, tissue regeneration, and cancer. Aberrant Eras expression has been linked to tumorigenesis in certain cancers, where it may promote proliferation and survival. The antibody's specificity for the N-terminal region ensures accurate detection of full-length Eras, aiding in distinguishing it from splice variants or degradation products. It is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to explore Eras localization, expression dynamics, and interaction networks. By enabling precise analysis of Eras in mouse models, this antibody contributes to understanding its physiological and pathological roles, offering potential insights into therapeutic strategies for cancer and regenerative medicine.
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