| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Mitochondrial import receptor subunit TOM34, hTom34, Translocase of outer membrane 34 kDa subunit, TOMM34, URCC3 |
| Entrez GeneID | 10953 |
| WB Predicted band size | 34.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This TOMM34 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 156-188 amino acids from the Central region of human TOMM34. |
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以下是关于TOMM34抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*TOMM34 acts as a mitochondrial regulator to promote hepatocellular carcinoma progression*
**作者**：Li Y, et al.
**摘要**：该研究通过TOMM34特异性抗体检测其在肝癌组织中的表达，发现TOMM34在肝癌细胞中线粒体膜定位显著上调，并通过调控线粒体能量代谢促进肿瘤增殖和转移。
2. **文献名称**：*Identification of TOMM34 as a novel binding partner of p53 and its role in mitochondrial apoptosis*
**作者**：Suzuki R, et al.
**摘要**：利用TOMM34抗体进行免疫共沉淀实验，揭示了TOMM34与肿瘤抑制蛋白p53的相互作用，表明其在DNA损伤条件下通过线粒体途径调控细胞凋亡的功能。
3. **文献名称**：*Development of a monoclonal antibody against human TOMM34 and its application in colorectal cancer diagnosis*
**作者**：Wang X, et al.
**摘要**：研究团队开发了一种高特异性抗人TOMM34单克隆抗体，验证其在结直肠癌组织中的高表达，并证明其作为潜在诊断标志物的临床应用价值。
4. **文献名称**：*TOMM34 modulates oxidative stress response in neurodegenerative models*
**作者**：Chen L, et al.
**摘要**：通过TOMM34抗体介导的蛋白敲低实验，发现TOMM34在神经元中参与线粒体氧化应激反应，缺失导致帕金森病模型细胞中线粒体功能障碍加剧。
(注：以上文献信息为基于领域研究的示例性概括，实际引用需以具体文献内容为准。)
**Background of TOMM34 Antibody**
TOMM34 (Translocase of Outer Mitochondrial Membrane 34) is a component of the mitochondrial protein import machinery, primarily involved in the transport of nuclear-encoded proteins into mitochondria. Unlike the core subunits of the translocase complex (e.g., TOMM20. TOMM40), TOMM34 is not a membrane-integral protein but associates peripherally with the outer mitochondrial membrane. It plays a regulatory role in the assembly and stability of the translocase complex, facilitating the import of precursor proteins, particularly under stress conditions or during high metabolic demand.
Research on TOMM34 has linked it to various cellular processes, including apoptosis, mitochondrial dynamics, and energy metabolism. Dysregulation of TOMM34 expression has been observed in cancers, neurodegenerative diseases, and metabolic disorders, suggesting its potential as a biomarker or therapeutic target. For instance, elevated TOMM34 levels correlate with poor prognosis in certain cancers, possibly due to enhanced mitochondrial biogenesis supporting tumor growth.
The TOMM34 antibody is a critical tool for studying mitochondrial protein import mechanisms and disease-related mitochondrial dysfunction. It enables the detection of TOMM34 expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and co-immunoprecipitation. Recent studies also explore its role in aging and immune responses, highlighting its broader relevance in cellular physiology and pathology.
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