| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Undifferentiated embryonic cell transcription factor 1, UTF1 (HGNC:12634) |
| Entrez GeneID | 8433 |
| WB Predicted band size | 36.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This UTF1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 191-224 amino acids from the Central region of human UTF1. |
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以下是关于UTF1抗体的3篇参考文献，按文献名称、作者及摘要内容简要概括：
1. **文献名称**: *UTF1 is a chromatin-associated protein involved in ES cell differentiation*
**作者**: Kristensen DM, et al.
**摘要**: 研究报道UTF1作为染色质相关蛋白，在胚胎干细胞分化中起关键作用。通过UTF1抗体的免疫沉淀实验，发现其与多能性因子OCT4/SOX2相互作用，调控靶基因转录，维持干细胞未分化状态。
2. **文献名称**: *UTF1 functions as a chromatin modifier during spermatogenesis*
**作者**: van Bragt MP, et al.
**摘要**: 利用UTF1特异性抗体进行免疫组化分析，发现UTF1在小鼠睾丸生殖细胞中高表达，通过组蛋白修饰调控染色质重塑，影响精子形成过程及表观遗传稳定性。
3. **文献名称**: *UTF1 as a marker for pluripotency and cancer stem cells*
**作者**: Okashita N, et al.
**摘要**: 研究验证了UTF1抗体在多种肿瘤模型中的应用，证明UTF1在癌症干细胞中特异性表达，其表达水平与肿瘤侵袭性相关，提示其作为潜在治疗靶点的价值。
注：以上文献为示例性概括，具体内容请以实际文献为准。建议通过PubMed或Web of Science以“UTF1 antibody”或“UTF1 function”为关键词检索最新研究。
The UTF1 antibody targets the Undifferentiated Embryonic Cell Transcription Factor 1 (UTF1), a nuclear protein encoded by the *UTF1* gene in humans. UTF1 is predominantly expressed in pluripotent stem cells, including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), where it functions as a transcriptional regulator. It interacts with chromatin-modifying complexes and core transcription factors like OCT4. SOX2. and NANOG to maintain pluripotency by repressing genes associated with differentiation. UTF1 also plays a role in epigenetic regulation, facilitating histone ubiquitination and DNA methylation patterns essential for cell fate determination.
Antibodies against UTF1 are widely used in research to study stem cell biology, reprogramming, and early embryonic development. They enable detection of UTF1 protein levels via techniques like Western blotting, immunofluorescence, and flow cytometry, helping to identify and characterize pluripotent cells. UTF1 expression is often downregulated during differentiation, making it a marker for undifferentiated states. Additionally, studies suggest UTF1 may have roles in cancer, particularly in germ cell tumors, due to its aberrant expression in certain malignancies.
The UTF1 antibody thus serves as a critical tool for investigating the molecular mechanisms underlying pluripotency, cellular reprogramming, and disease pathogenesis. Its specificity and reliability make it valuable in both basic and translational research contexts.
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