| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/25 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Mitogen-activated protein kinase 11, MAP kinase 11, MAPK 11, Mitogen-activated protein kinase p38 beta, MAP kinase p38 beta, p38B, Mapk11, Prkm11 |
| Entrez GeneID | 19094 |
| WB Predicted band size | 41.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This Mouse Mapk11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of mouse Mapk11. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Mouse MAPK11 (N-term)抗体的3篇参考文献示例，内容基于典型研究场景概括：
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1. **文献名称**：*Characterization of p38 MAP kinase isoforms in mouse macrophages*
**作者**：Li X, et al.
**摘要**：研究利用N端特异性MAPK11抗体(p38β)分析小鼠巨噬细胞中p38 MAPK家族的表达模式，发现MAPK11在炎症反应中与TNF-α信号通路特异性关联。
2. **文献名称**：*Role of MAPK11 in oxidative stress-induced neuronal apoptosis*
**作者**：Chen H, et al.
**摘要**：通过Western blot和免疫荧光(使用N-terminal MAPK11抗体)，证实MAPK11在小鼠神经元氧化应激模型中激活，并调控Caspase-3依赖性凋亡通路。
3. **文献名称**：*Development and validation of antibodies targeting murine MAPK family members*
**作者**：Smith J, et al.
**摘要**：报道了针对小鼠MAPK家族(包括MAPK11 N端表位)的多克隆抗体制备，验证其特异性应用于免疫沉淀和组织切片染色，确认其在心脏缺血模型中的表达变化。
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注：以上文献为示例性概括，实际引用需根据具体研究查询PubMed或SciFinder获取真实文献(如涉及实验细节，建议补充DOI或PMID)。
The Mouse MAPK11 (N-term) antibody is designed to specifically detect the N-terminal region of mitogen-activated protein kinase 11 (MAPK11), also known as p38 beta, a member of the serine/threonine protein kinase family. MAPK11 is part of the p38 MAPK subfamily, which plays critical roles in cellular responses to stress, cytokines, and growth factors. It regulates processes like apoptosis, differentiation, and immune responses by phosphorylating downstream targets. The N-terminal region targeted by this antibody is crucial for kinase activity and interaction with upstream activators, such as MAP kinase kinases (MKKs).
This antibody is commonly used in applications like Western blotting, immunohistochemistry, and immunofluorescence to study MAPK11 expression, activation, and localization in mouse tissues or cell lines. Its specificity for the N-terminus helps distinguish MAPK11 from other p38 isoforms (e.g., p38 alpha, gamma, delta) and minimizes cross-reactivity. Researchers often employ it to investigate MAPK11's role in signaling pathways linked to inflammation, cancer, or neurodegenerative diseases. Validation typically includes testing in MAPK11-knockout models to confirm specificity. As a tool, it aids in elucidating tissue-specific functions or stress-response mechanisms mediated by this kinase in murine systems.
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