| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 1/25 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | COP9 signalosome complex subunit 2, SGN2, Signalosome subunit 2, Alien homolog, JAB1-containing signalosome subunit 2, Thyroid receptor-interacting protein 15, TR-interacting protein 15, TRIP-15, COPS2, CSN2, TRIP15 |
| Entrez GeneID | 9318 |
| WB Predicted band size | 51.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This COPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human COPS2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于COPS2(N-term)抗体的参考文献示例(内容为模拟，建议通过学术数据库核实具体文献)：
---
1. **文献名称**：*COPS2 promotes tumor progression by regulating the stability of oncogenic proteins in breast cancer*
**作者**：Smith J, et al. (2020)
**摘要**：本研究利用COPS2(N-term)抗体进行Western blot和免疫沉淀实验，发现COPS2在乳腺癌中过表达，并通过稳定c-Myc等蛋白促进肿瘤生长。抗体特异性通过siRNA敲低验证。
2. **文献名称**：*The COP9 signalosome subunit COPS2 interacts with c-Jun to modulate AP-1 signaling*
**作者**：Lee H, et al. (2018)
**摘要**：通过COPS2(N-term)抗体的免疫共沉淀和免疫荧光实验，揭示了COPS2与转录因子c-Jun的直接结合，调控AP-1信号通路的活性，影响细胞增殖和凋亡。
3. **文献名称**：*COPS2 deficiency disrupts cell cycle progression via impaired ubiquitin-dependent proteolysis*
**作者**：Zhang R, et al. (2016)
**摘要**：研究使用COPS2(N-term)抗体进行组织染色和流式细胞术，发现COPS2缺失导致细胞周期蛋白异常积累，从而引发G1/S期阻滞，强调其在泛素-蛋白酶体系统中的关键作用。
---
**注意**：以上为模拟生成的参考文献，实际文献需通过PubMed、Google Scholar等平台以关键词“COPS2 N-term antibody”或“COPS2 antibody N-terminal”检索，并筛选涉及该抗体应用的实验研究(如WB、IP、IF等)。部分商业抗体产品(如Abcam #ab125965)的技术手册也可能提供引用案例。
The COPS2 (N-term) antibody is designed to target the N-terminal region of the COPS2 protein (also known as CSN2), a key component of the COP9 signalosome (CSN) complex. The COP9 signalosome is a highly conserved, multi-subunit protein complex involved in regulating ubiquitin-proteasome-mediated protein degradation. COPS2 plays a critical role in maintaining the structural integrity of the CSN complex and modulating its enzymatic activities, such as deneddylation (removal of NEDD8 post-translational modifiers) and deubiquitination. These processes are essential for controlling protein stability, DNA damage response, cell cycle progression, and signaling pathways like JNK and p53. Dysregulation of COPS2 has been linked to cancers, developmental disorders, and neurodegenerative diseases.
The COPS2 (N-term) antibody is commonly used in applications like Western blotting, immunoprecipitation, and immunofluorescence to detect endogenous COPS2 protein levels and localization. Its specificity is often validated using COPS2-deficient cell lines or siRNA-mediated knockdown to confirm the absence of cross-reactivity with other CSN subunits. Researchers employ this antibody to investigate COPS2's role in cellular processes, disease mechanisms, and its interaction with other signaling molecules. By targeting the N-terminal region, the antibody avoids potential interference with conserved CSN complex-binding domains, ensuring accurate detection in experimental models.
×
