| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Glutamate receptor ionotropic, NMDA 2C, GluN2C, Glutamate [NMDA] receptor subunit epsilon-3, N-methyl D-aspartate receptor subtype 2C, NMDAR2C, NR2C, GRIN2C, NMDAR2C |
| Entrez GeneID | 2905 |
| WB Predicted band size | 134.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This GRIN2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 567-595 amino acids from the Central region of human GRIN2C. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GRIN2C抗体的3篇参考文献示例，包含文献名称、作者及摘要概括：
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1. **文献名称**: "Differential Expression of NMDA Receptor Subunits in the Adult Mouse Brain"
**作者**: Monyer, H., Burnashev, N., Laurie, D. J., et al.
**摘要**: 本研究通过免疫组化和原位杂交技术，系统分析了NMDA受体亚基(包括GRIN2C)在小脑、丘脑等脑区的分布差异。结果显示GRIN2C在小脑颗粒细胞中高表达，提示其在小脑功能中的特异性作用。
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2. **文献名称**: "Selective Localization of GluN2C Subunits in Cerebellar Synapses Revealed by a Novel GRIN2C-Specific Antibody"
**作者**: Akazawa, C., Shigemoto, R., Bessho, Y., et al.
**摘要**: 研究者开发了一种高特异性GRIN2C抗体，通过免疫电镜和免疫荧光技术，证实GRIN2C蛋白主要富集于小脑平行纤维-浦肯野细胞突触中，揭示了其在突触可塑性中的潜在调控机制。
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3. **文献名称**: "Altered Expression of NMDA Receptor Subunits in Epileptic Cortex: A Comparative Study Using GRIN2A and GRIN2C Antibodies"
**作者**: Hansen, K. B., Yuan, H., & Traynelis, S. F.
**摘要**: 该研究利用GRIN2C抗体进行免疫印迹和免疫组织化学分析，发现癫痫模型小鼠皮层中GRIN2C蛋白表达显著下调，提示其异常表达可能与癫痫病理中的神经元过度兴奋相关。
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注：以上文献信息为示例，实际引用时需核实文献是否存在及具体细节。如需真实文献，建议通过PubMed或Google Scholar以关键词“GRIN2C antibody”或“GluN2C subunit”检索。
The GRIN2C antibody targets the GluN2C subunit encoded by the GRIN2C gene, a critical component of N-methyl-D-aspartate (NMDA) receptors. These receptors are ionotropic glutamate-gated channels essential for synaptic plasticity, learning, and memory. The GluN2C subunit, one of four GluN2 variants (GluN2A-D), confers distinct functional and pharmacological properties to NMDA receptors. Compared to other subunits, GluN2C-containing receptors exhibit lower calcium permeability, slower deactivation kinetics, and unique sensitivity to modulators like zinc and protons.
GRIN2C is predominantly expressed in specific brain regions, including the cerebellum, thalamus, and olfactory bulb, and its expression peaks during early postnatal development. This spatiotemporal specificity suggests roles in neural circuit maturation and sensory processing. Dysregulation of GRIN2C has been implicated in neurological disorders such as epilepsy, schizophrenia, and neurodegenerative diseases.
GRIN2C antibodies are widely used in neuroscience research to map protein expression, investigate receptor localization, and assess changes in pathological conditions. They enable techniques like Western blotting, immunohistochemistry, and immunoprecipitation. Validating these antibodies is crucial, as cross-reactivity with other GluN2 subunits can occur. Recent studies also explore GRIN2C's therapeutic potential, with antibodies aiding in drug discovery targeting NMDA receptor dysfunction. Understanding GRIN2C biology remains vital for deciphering synaptic mechanisms and developing precision treatments for brain disorders.
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