| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Calsyntenin-2, Alcadein-gamma, Alc-gamma, CLSTN2, CS2 |
| Entrez GeneID | 64084 |
| WB Predicted band size | 107.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This CLSTN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 743-770 amino acids from the Central region of human CLSTN2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CLSTN2抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*"Calsyntenin-2 regulates spatial learning and depressive-like behaviors through CLSTN2-amyloid precursor protein interaction"*
**作者**：Smith A et al.
**摘要**：研究利用CLSTN2特异性抗体揭示了其与淀粉样前体蛋白(APP)的相互作用，发现CLSTN2缺失导致小鼠空间学习能力下降和抑郁样行为，提示其在神经退行性疾病中的潜在作用。
2. **文献名称**：*"Development and characterization of a novel monoclonal antibody targeting the extracellular domain of CLSTN2"*
**作者**：Zhang L et al.
**摘要**：该研究开发了一种靶向CLSTN2胞外域的高特异性单克隆抗体，验证了其在Western blot、免疫组化和免疫沉淀中的有效性，为后续功能研究提供了工具。
3. **文献名称**：*"CLSTN2 modulates excitatory synaptic transmission and dendritic spine morphology"*
**作者**：Kimura T et al.
**摘要**：通过CLSTN2抗体进行免疫染色，发现CLSTN2通过调控钙信号影响兴奋性突触传递和树突棘形态，其缺失导致小鼠海马突触可塑性异常。
4. **文献名称**：*"Calsyntenin-2 antibody reveals dynamic expression patterns in the developing mouse brain"*
**作者**：Johnson R et al.
**摘要**：利用新开发的CLSTN2抗体追踪其在小鼠胚胎期至成年期的表达，发现其在神经元迁移和突触形成阶段高表达，提示其对神经发育的关键作用。
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**注**：以上文献为示例，实际研究中建议通过PubMed或Web of Science以关键词“CLSTN2 antibody”或“Calsyntenin-2 function”检索最新文献。
The CLSTN2 (Center) antibody is a research tool designed to target the central region of the calsyntenin-2 (CLSTN2) protein, a member of the calsyntenin family. CLSTN2. also known as alcadein-β, is a type I transmembrane protein predominantly expressed in the central nervous system. It plays critical roles in synaptic organization, neuronal trafficking, and intracellular signaling. Structurally, CLSTN2 contains conserved extracellular cadherin-like domains, a single transmembrane segment, and a cytoplasmic tail that interacts with adaptor proteins like X11L/Mint2. linking it to synaptic vesicle transport and amyloid precursor protein (APP) processing. Dysregulation of CLSTN2 has been implicated in neurodevelopmental and neurodegenerative disorders, including Alzheimer’s disease, due to its interaction with APP and potential influence on amyloid-β production.
The CLSTN2 (Center) antibody is commonly used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to detect endogenous CLSTN2 expression and localization in brain tissues or neuronal cell models. Its specificity for the central region ensures recognition of full-length or processed forms of the protein, aiding studies on CLSTN2’s functional roles and pathological mechanisms. Researchers utilize this antibody to explore CLSTN2’s involvement in synaptic plasticity, axonal transport, and disease-associated pathways, contributing to broader insights into neural circuit dysfunction and therapeutic target discovery. Validation typically includes knockout controls and epitope mapping to confirm reliability.
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