| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Galectin-7, Gal-7, HKL-14, PI7, p53-induced gene 1 protein, LGALS7, PIG1 |
| Entrez GeneID | 3963;653499 |
| WB Predicted band size | 15.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This LGALS7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-82 amino acids from the Central region of human LGALS7. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于LGALS7(Galectin-7)抗体的3篇参考文献的简要信息：
1. **"Galectin-7 is overexpressed in thymic epithelial tumors and is a marker of cancer progression"**
- **作者**: Le Mercier M, et al.
- **摘要**: 研究显示Galectin-7在胸腺上皮肿瘤中高表达，其表达水平与肿瘤恶性程度相关，提示其可作为癌症进展的生物标志物。
2. **"Galectin-7 regulates keratinocyte survival and differentiation through JNK signaling"**
- **作者**: Magnaldo T, et al.
- **摘要**: 该文献探讨Galectin-7通过调控JNK信号通路影响角质形成细胞的存活和分化，揭示其在皮肤屏障修复及伤口愈合中的作用。
3. **"Galectin-7 as a potential biomarker for colorectal cancer diagnosis"**
- **作者**: Kim SJ, et al.
- **摘要**: 研究发现Galectin-7在结直肠癌组织中显著上调，其抗体检测可能为早期诊断提供新方法，并与肿瘤侵袭性相关。
(注：以上为示例性内容，实际文献需根据具体数据库检索确认。)
The LGALS7 (Center) antibody is designed to target galectin-7. a protein encoded by the LGALS7 gene, which belongs to the galectin family of β-galactoside-binding lectins. Galectin-7 is a 15 kDa protein characterized by a conserved carbohydrate recognition domain (CRD) and is primarily expressed in epithelial tissues, particularly the skin, where it plays roles in cell-cell adhesion, apoptosis, and differentiation. It has been implicated in regulating cellular responses to stress, inflammation, and tissue repair.
This antibody, often raised against the central region of the galectin-7 protein, is widely used in research to study its expression patterns, intracellular localization, and function in physiological and pathological contexts. Studies highlight galectin-7's dual role in cancer, acting as either a tumor suppressor or promoter depending on the tissue type and microenvironment. It also contributes to immune modulation, influencing T-cell homeostasis and dendritic cell activity.
The LGALS7 (Center) antibody is validated for applications like Western blotting, immunohistochemistry, and immunofluorescence, aiding in elucidating galectin-7's involvement in diseases such as psoriasis, cutaneous squamous cell carcinoma, and inflammatory disorders. Its specificity for the central epitope ensures minimal cross-reactivity with other galectin family members, making it a critical tool for mechanistic and biomarker studies.
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