Rabbit Polyclonal DPEP1(N-term) Antibody

The DPEP1 (N-term) antibody targets the N-terminal region of dipeptidase 1 (DPEP1), a membrane-bound glycoprotein belonging to the metalloprotease M19 family. DPEP1. also known as renal dipeptidase, plays a role in hydrolyzing dipeptides, particularly those containing cysteine-glycine bonds, and is involved in the metabolism of leukotrienes and glutathione derivatives. It is primarily expressed in the kidney, lung, and intestinal brush-border membranes, with implications in physiological processes and diseases such as renal dysfunction, inflammation, and cancer. The antibody is commonly used in research to study DPEP1's expression, localization, and function via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its specificity for the N-terminal epitope allows researchers to distinguish DPEP1 from structurally related enzymes or splice variants. DPEP1 has gained attention in oncology due to its potential role as a biomarker or therapeutic target in certain cancers, including liver and colorectal malignancies. The antibody's applications extend to investigating DPEP1's interaction with nephrotoxic drugs like cilastatin, which inhibits its enzymatic activity. Validation of DPEP1 (N-term) antibodies typically includes knockout cell line controls to confirm specificity, ensuring reliable detection in experimental models.