| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Granulocyte colony-stimulating factor, G-CSF, Pluripoietin, Filgrastim, Lenograstim, CSF3, C17orf33, GCSF |
| Entrez GeneID | 1440 |
| WB Predicted band size | 22.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CSF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-207 amino acids from the C-terminal region of human CSF3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CSF3(C-term)抗体的3篇代表性文献的简要信息(注：文献为示例性内容，实际引用需核实原文)：
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1. **文献名称**: *Structural characterization of human granulocyte colony-stimulating factor (G-CSF) and antibody interaction*
**作者**: Hill CP, et al.
**摘要**: 该研究解析了G-CSF(CSF3)的C端结构域与其特异性抗体的结合机制，通过X射线晶体学揭示了抗体对C端表位的识别模式，为开发高亲和力检测工具提供了依据。
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2. **文献名称**: *Development of a C-terminal-specific monoclonal antibody for G-CSF quantification in clinical samples*
**作者**: Kubota N, et al.
**摘要**: 研究团队开发了一种针对G-CSF C末端的单克隆抗体，建立了一种高灵敏度的ELISA检测方法，成功应用于白血病患者血清中G-CSF水平的定量分析，验证了其临床诊断价值。
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3. **文献名称**: *Role of the C-terminal domain in G-CSF receptor binding and signaling*
**作者**: Muto T, et al.
**摘要**: 利用C端特异性抗体阻断实验，本研究证实G-CSF的C末端结构域对其受体二聚化及下游信号通路的激活至关重要，为靶向治疗策略提供了新见解。
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**备注**：以上文献信息为模拟示例，实际引用需通过学术数据库(如PubMed)检索真实文献。建议使用关键词“G-CSF C-terminal antibody”或“CSF3 epitope mapping”进一步查找。
The CSF3 (C-term) antibody is a specialized immunological tool designed to target the C-terminal region of Colony Stimulating Factor 3 (CSF3), also known as Granulocyte Colony-Stimulating Factor (G-CSF). CSF3 is a cytokine critical for regulating neutrophil production, differentiation, and survival by binding to its receptor (G-CSFR) on hematopoietic precursor cells. The C-terminal domain of CSF3 plays a role in receptor interaction and downstream signaling, making it a focal point for studying G-CSF-mediated biological processes.
This antibody is commonly employed in research applications such as Western blotting, immunohistochemistry, and ELISA to detect endogenous or recombinant CSF3 protein in various biological samples. Its specificity for the C-terminal region ensures minimal cross-reactivity with other cytokines or structurally related proteins, enhancing experimental accuracy. Researchers utilize this tool to investigate CSF3 expression patterns in contexts like immune responses, hematopoiesis, and cancer biology. For example, it aids in exploring CSF3's role in mitigating chemotherapy-induced neutropenia, promoting stem cell mobilization, or modulating tumor-associated inflammation.
Additionally, the CSF3 (C-term) antibody supports studies on diseases linked to CSF3 dysregulation, such as congenital neutropenia, leukemia, or autoimmune disorders. Its validation in multiple species (e.g., human, mouse) broadens its utility across preclinical models. By enabling precise detection of CSF3. this antibody contributes to advancing therapeutic strategies, including G-CSF-based therapies and biomarker discovery.
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