| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transmembrane protein 158, 40 kDa BINP-binding protein, p40BBP, Ras-induced senescence protein 1, Tmem158, Mbbp, Ris1 |
| WB Predicted band size | 29.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Tmem158 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 179-206 amino acids from the Central region of mouse Tmem158. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于小鼠Tmem158(Center)抗体的参考文献示例(内容为虚构示例，仅供参考格式)：
1. **文献名称**: "Tmem158 regulates hippocampal neurogenesis in Alzheimer's mouse models"
**作者**: Smith A, et al.
**摘要**: 研究通过Tmem158(Center)抗体检测小鼠海马区Tmem158蛋白表达，发现其在阿尔茨海默病模型中的表达水平与神经元再生受损相关。
2. **文献名称**: "Characterization of Tmem158 as a biomarker in glioma progression"
**作者**: Zhang L, et al.
**摘要**: 利用Tmem158(Center)特异性抗体进行免疫组化分析，证实Tmem158在小鼠神经胶质瘤模型中高表达，并与肿瘤侵袭性相关。
3. **文献名称**: "Tmem158 modulates neuronal apoptosis via MAPK signaling"
**作者**: Lee J, et al.
**摘要**: 通过Western blot和免疫荧光(使用Tmem158-Center抗体)发现，Tmem158敲除小鼠中神经元凋亡减少，提示其通过MAPK通路调控细胞死亡。
4. **文献名称**: "Tmem158 as a therapeutic target in pancreatic cancer metastasis"
**作者**: Patel R, et al.
**摘要**: 研究使用Tmem158(Center)抗体检测小鼠胰腺癌转移模型，发现抑制Tmem158可显著降低肿瘤转移能力。
注：以上文献为示例，实际引用需根据真实研究调整。建议通过PubMed或Google Scholar以关键词“Mouse Tmem158 antibody”或“Tmem158 (Center)”检索具体文献。
The TMEM158 (Transmembrane Protein 158) gene encodes a conserved transmembrane protein implicated in cellular processes like proliferation, apoptosis, and stress response. Studies suggest its involvement in neurodegenerative diseases (e.g., Parkinson’s) and cancer, where it may act as a Ras-responsive factor promoting tumorigenesis or as a regulator of lysosomal function in neurons. The "Center" epitope in Mouse Tmem158 antibodies typically targets an internal region of the protein, enabling detection of full-length or processed forms in various applications.
Mouse Tmem158 antibodies are widely used in neuroscience and oncology research to investigate protein expression, localization (e.g., lysosomal/endosomal compartments), and disease mechanisms. They are validated in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), often using knockout controls to confirm specificity. Recent studies highlight Tmem158's role in modulating mTOR signaling, autophagy, and neuroinflammation, making these antibodies critical tools for exploring its dual roles in cell survival pathways and pathological contexts. Commercial antibodies are usually raised against recombinant mouse Tmem158 fragments, ensuring species-specific reactivity. Researchers should verify experimental conditions (e.g., tissue fixation, epitope accessibility) to optimize detection.
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